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Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

Voltage-gated sodium channels (Nav) are essential for the initiation and propagation of action potentials in neurons. Of the nine human channel subtypes, Nav1.1, Nav1.2 and Nav1.6 are prominently expressed in the adult central nervous system (CNS). All three of these sodium channel subtypes are sens...

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Detalles Bibliográficos
Autores principales:	Thouta, Samrat, Waldbrook, Matthew G., Lin, Sophia, Mahadevan, Arjun, Mezeyova, Janette, Soriano, Maegan, Versi, Pareesa, Goodchild, Samuel J., Parrish, R. Ryley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557217/ https://www.ncbi.nlm.nih.gov/pubmed/36246527 http://dx.doi.org/10.3389/fncel.2022.964691

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