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The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma
Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557223/ https://www.ncbi.nlm.nih.gov/pubmed/36249029 http://dx.doi.org/10.3389/fonc.2022.1009984 |
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author | Wang, Jin Qi, Xiaochen Wang, Qifei Wu, Guangzhen |
author_facet | Wang, Jin Qi, Xiaochen Wang, Qifei Wu, Guangzhen |
author_sort | Wang, Jin |
collection | PubMed |
description | Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells rely on the anoikis resistance of cancer cells. Bioinformatics analysis was performed to confirm the relation of anoikis to kidney renal cell carcinoma (KIRC). To construct a prognostic model for patients with KIRC, we investigated several genes of the anoikis pathway most closely related to KIRC and also contrasted the effects of common anticancer drugs on the KIRC pathway. Besides KIRC, we explored the expression of anoikis-related genes in various other cancers. We classified patients with KIRC into three clusters based on the coefficients and mRNA expression levels of anoikis-related genes selected using the GSVA algorithm. We used the GDSC database to predict the response of the anoikis pathway to common anticancer drugs and explored the potential targets of the anoikis pathway in KIRC. We then analyzed the response of common immunotherapies to the anoikis pathway to analyze the correlation between anoikis and immune checkpoint inhibitor therapy. Finally, eleven cancer-related genes were screened and a prognostic model was constructed using LASSO regression. |
format | Online Article Text |
id | pubmed-9557223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95572232022-10-14 The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma Wang, Jin Qi, Xiaochen Wang, Qifei Wu, Guangzhen Front Oncol Oncology Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells rely on the anoikis resistance of cancer cells. Bioinformatics analysis was performed to confirm the relation of anoikis to kidney renal cell carcinoma (KIRC). To construct a prognostic model for patients with KIRC, we investigated several genes of the anoikis pathway most closely related to KIRC and also contrasted the effects of common anticancer drugs on the KIRC pathway. Besides KIRC, we explored the expression of anoikis-related genes in various other cancers. We classified patients with KIRC into three clusters based on the coefficients and mRNA expression levels of anoikis-related genes selected using the GSVA algorithm. We used the GDSC database to predict the response of the anoikis pathway to common anticancer drugs and explored the potential targets of the anoikis pathway in KIRC. We then analyzed the response of common immunotherapies to the anoikis pathway to analyze the correlation between anoikis and immune checkpoint inhibitor therapy. Finally, eleven cancer-related genes were screened and a prognostic model was constructed using LASSO regression. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9557223/ /pubmed/36249029 http://dx.doi.org/10.3389/fonc.2022.1009984 Text en Copyright © 2022 Wang, Qi, Wang and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wang, Jin Qi, Xiaochen Wang, Qifei Wu, Guangzhen The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
title | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
title_full | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
title_fullStr | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
title_full_unstemmed | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
title_short | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
title_sort | role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557223/ https://www.ncbi.nlm.nih.gov/pubmed/36249029 http://dx.doi.org/10.3389/fonc.2022.1009984 |
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