Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell inhibition

BACKGROUND: Colorectal cancer (CRC) has a high mortality rate and can develop in either colitis-dependent (colitis-associated (CA)-CRC) or colitis-independent (sporadic (s)CRC) manner. There has been a significant debate about whether mast cells (MCs) promote or inhibit the development of CRC. Herei...

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Detalles Bibliográficos
Autores principales: Sakita, Juliana Y, Elias-Oliveira, Jefferson, Carlos, Daniela, de Souza Santos, Emerson, Almeida, Luciana Yamamoto, Malta, Tathiane M, Brunaldi, Mariângela O, Albuquerque, Sergio, Araújo Silva, Cleide Lúcia, Andrade, Marcus V, Bonato, Vania L D, Garcia, Sergio Britto, Cunha, Fernando Queiroz, Cebinelli, Guilherme Cesar Martelossi, Martins, Ronaldo B, Matthews, Jason, Colli, Leandro, Martin, Francis L, Uyemura, Sergio A, Kannen, Vinicius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557261/
https://www.ncbi.nlm.nih.gov/pubmed/36220303
http://dx.doi.org/10.1136/jitc-2022-004653

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