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Systematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6

TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II preinitiation complex, TFIIH regulates pol II enzyme activity in numerous ways. The TFIIH subunit XPB/Ssl2 is an ATP-dependent...

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Detalles Bibliográficos
Autores principales:	Bassett, Jacob, Rimel, Jenna K., Basu, Shrabani, Basnet, Pratik, Luo, Jie, Engel, Krysta L., Nagel, Michael, Woyciehowsky, Alexander, Ebmeier, Christopher C., Kaplan, Craig D., Taatjes, Dylan J., Ranish, Jeffrey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557730/ https://www.ncbi.nlm.nih.gov/pubmed/36041630 http://dx.doi.org/10.1016/j.jbc.2022.102433

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