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Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China
oXiris is a new, high-adsorption membrane filter in continuous hemofiltration adsorption to reduce the inflammatory response in sepsis. The investigators retrospectively reviewed patients with sepsis/septic shock who underwent at least one oXiris-treatment from November 2020 to March 2022. The demog...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557776/ https://www.ncbi.nlm.nih.gov/pubmed/36249210 http://dx.doi.org/10.3389/fpubh.2022.1012998 |
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author | Zhou, Yanyan Wu, Chenfang Ouyang, Lin Peng, Ying Zhong, Dingming Xiang, Xiaohong Li, Jinxiu |
author_facet | Zhou, Yanyan Wu, Chenfang Ouyang, Lin Peng, Ying Zhong, Dingming Xiang, Xiaohong Li, Jinxiu |
author_sort | Zhou, Yanyan |
collection | PubMed |
description | oXiris is a new, high-adsorption membrane filter in continuous hemofiltration adsorption to reduce the inflammatory response in sepsis. The investigators retrospectively reviewed patients with sepsis/septic shock who underwent at least one oXiris-treatment from November 2020 to March 2022. The demographic data, baseline levels before treatment, clinical datas, prognosis, and the occurrence of adverse events during treatment were recorded. 90 patients were enrolled in this study. The hemodynamic indices, sequential organ failure assessment score, lactate, inflammatory biomarkers levels were significantly improved at 12 h and 24 h after treatment. Procalcitonin and interleukin-6 reduction post-treatment of oXiris were most pronounced in infection from skin and soft tissue, urinary and abdominal cavity. Logistic regression analysis showed that pre-treatment sequential organ failure assessment score (p = 0.034), percentage decrease in sequential organ failure assessment score (p = 0.004), and age (p = 0.011) were independent risk factors for intensive care unit mortality. In conclusion, oXiris-continuous hemofiltration adsorption may improve hemodynamic indicators, reduce the use of vasoactive drugs, reduce lactate level and infection indicators. Of note, oXiris improve organ function in sepsis, which may result to higher survival rate. |
format | Online Article Text |
id | pubmed-9557776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95577762022-10-14 Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China Zhou, Yanyan Wu, Chenfang Ouyang, Lin Peng, Ying Zhong, Dingming Xiang, Xiaohong Li, Jinxiu Front Public Health Public Health oXiris is a new, high-adsorption membrane filter in continuous hemofiltration adsorption to reduce the inflammatory response in sepsis. The investigators retrospectively reviewed patients with sepsis/septic shock who underwent at least one oXiris-treatment from November 2020 to March 2022. The demographic data, baseline levels before treatment, clinical datas, prognosis, and the occurrence of adverse events during treatment were recorded. 90 patients were enrolled in this study. The hemodynamic indices, sequential organ failure assessment score, lactate, inflammatory biomarkers levels were significantly improved at 12 h and 24 h after treatment. Procalcitonin and interleukin-6 reduction post-treatment of oXiris were most pronounced in infection from skin and soft tissue, urinary and abdominal cavity. Logistic regression analysis showed that pre-treatment sequential organ failure assessment score (p = 0.034), percentage decrease in sequential organ failure assessment score (p = 0.004), and age (p = 0.011) were independent risk factors for intensive care unit mortality. In conclusion, oXiris-continuous hemofiltration adsorption may improve hemodynamic indicators, reduce the use of vasoactive drugs, reduce lactate level and infection indicators. Of note, oXiris improve organ function in sepsis, which may result to higher survival rate. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9557776/ /pubmed/36249210 http://dx.doi.org/10.3389/fpubh.2022.1012998 Text en Copyright © 2022 Zhou, Wu, Ouyang, Peng, Zhong, Xiang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Zhou, Yanyan Wu, Chenfang Ouyang, Lin Peng, Ying Zhong, Dingming Xiang, Xiaohong Li, Jinxiu Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China |
title | Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China |
title_full | Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China |
title_fullStr | Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China |
title_full_unstemmed | Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China |
title_short | Application of oXiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: A single-centre experience in China |
title_sort | application of oxiris-continuous hemofiltration adsorption in patients with sepsis and septic shock: a single-centre experience in china |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557776/ https://www.ncbi.nlm.nih.gov/pubmed/36249210 http://dx.doi.org/10.3389/fpubh.2022.1012998 |
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