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Metabolomics Analysis of Chronic Exposure to Dimethylarsenic Acid in Mice and Toxicity Assessment of Organic Arsenic in Food
[Image: see text] Dimethylarsenic acid is a natural organic arsenic in seafood and one of the important metabolites of inorganic arsenic, which is generally considered to have low or no toxicity. However, due to the controversy of the toxicity of organic arsenic, the food safety standard of organic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557882/ https://www.ncbi.nlm.nih.gov/pubmed/36249356 http://dx.doi.org/10.1021/acsomega.2c03806 |
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author | Jing, Nan Peng, Jing Yang, Xin Wang, Xinzheng Liu, Qian Wang, Hongli Li, Weihua Dong, Fangting He, Kun Wang, Na |
author_facet | Jing, Nan Peng, Jing Yang, Xin Wang, Xinzheng Liu, Qian Wang, Hongli Li, Weihua Dong, Fangting He, Kun Wang, Na |
author_sort | Jing, Nan |
collection | PubMed |
description | [Image: see text] Dimethylarsenic acid is a natural organic arsenic in seafood and one of the important metabolites of inorganic arsenic, which is generally considered to have low or no toxicity. However, due to the controversy of the toxicity of organic arsenic, the food safety standard of organic arsenic has not been established until now, and the effects of organic arsenic on chronic toxicity and the overall metabolic level of animals are rarely reported. In our study, 64 female C57BL/6 mice were exposed to different concentrations of dimethylarsenic acid with water intake. Fifteen metabolites in serum were detected to be altered with the increase of arsenic concentration and exposure time. Dimethylarsenic acid exposure significantly affected the overall metabolic level of mice, and the related effects were not recovered shortly after the suspension of arsenic intake. Although arsenic was excreted largely in urine and feces, continued dimethylarsenic acid exposure could still lead to arsenic accumulation in the liver and kidneys and cause mild nephritis in mice. |
format | Online Article Text |
id | pubmed-9557882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-95578822022-10-14 Metabolomics Analysis of Chronic Exposure to Dimethylarsenic Acid in Mice and Toxicity Assessment of Organic Arsenic in Food Jing, Nan Peng, Jing Yang, Xin Wang, Xinzheng Liu, Qian Wang, Hongli Li, Weihua Dong, Fangting He, Kun Wang, Na ACS Omega [Image: see text] Dimethylarsenic acid is a natural organic arsenic in seafood and one of the important metabolites of inorganic arsenic, which is generally considered to have low or no toxicity. However, due to the controversy of the toxicity of organic arsenic, the food safety standard of organic arsenic has not been established until now, and the effects of organic arsenic on chronic toxicity and the overall metabolic level of animals are rarely reported. In our study, 64 female C57BL/6 mice were exposed to different concentrations of dimethylarsenic acid with water intake. Fifteen metabolites in serum were detected to be altered with the increase of arsenic concentration and exposure time. Dimethylarsenic acid exposure significantly affected the overall metabolic level of mice, and the related effects were not recovered shortly after the suspension of arsenic intake. Although arsenic was excreted largely in urine and feces, continued dimethylarsenic acid exposure could still lead to arsenic accumulation in the liver and kidneys and cause mild nephritis in mice. American Chemical Society 2022-09-29 /pmc/articles/PMC9557882/ /pubmed/36249356 http://dx.doi.org/10.1021/acsomega.2c03806 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Jing, Nan Peng, Jing Yang, Xin Wang, Xinzheng Liu, Qian Wang, Hongli Li, Weihua Dong, Fangting He, Kun Wang, Na Metabolomics Analysis of Chronic Exposure to Dimethylarsenic Acid in Mice and Toxicity Assessment of Organic Arsenic in Food |
title | Metabolomics Analysis
of Chronic Exposure to Dimethylarsenic
Acid in Mice and Toxicity Assessment of Organic Arsenic in Food |
title_full | Metabolomics Analysis
of Chronic Exposure to Dimethylarsenic
Acid in Mice and Toxicity Assessment of Organic Arsenic in Food |
title_fullStr | Metabolomics Analysis
of Chronic Exposure to Dimethylarsenic
Acid in Mice and Toxicity Assessment of Organic Arsenic in Food |
title_full_unstemmed | Metabolomics Analysis
of Chronic Exposure to Dimethylarsenic
Acid in Mice and Toxicity Assessment of Organic Arsenic in Food |
title_short | Metabolomics Analysis
of Chronic Exposure to Dimethylarsenic
Acid in Mice and Toxicity Assessment of Organic Arsenic in Food |
title_sort | metabolomics analysis
of chronic exposure to dimethylarsenic
acid in mice and toxicity assessment of organic arsenic in food |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557882/ https://www.ncbi.nlm.nih.gov/pubmed/36249356 http://dx.doi.org/10.1021/acsomega.2c03806 |
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