Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine

[Image: see text] Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and...

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Autores principales: Gayke, Manoj, Hirapara, Nirbhay, Narode, Hanuman, Bhosle, Siddhanath D., Bhosale, Rajesh S., Yadav, Jhillu Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557893/
https://www.ncbi.nlm.nih.gov/pubmed/36249350
http://dx.doi.org/10.1021/acsomega.2c05350
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author Gayke, Manoj
Hirapara, Nirbhay
Narode, Hanuman
Bhosle, Siddhanath D.
Bhosale, Rajesh S.
Yadav, Jhillu Singh
author_facet Gayke, Manoj
Hirapara, Nirbhay
Narode, Hanuman
Bhosle, Siddhanath D.
Bhosale, Rajesh S.
Yadav, Jhillu Singh
author_sort Gayke, Manoj
collection PubMed
description [Image: see text] Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and its derivative. The utility of zinc chloride over other catalysts such as zinc dust and zinc acetate exhibits a 49–87% yield of carbamates.
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spelling pubmed-95578932022-10-14 Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine Gayke, Manoj Hirapara, Nirbhay Narode, Hanuman Bhosle, Siddhanath D. Bhosale, Rajesh S. Yadav, Jhillu Singh ACS Omega [Image: see text] Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and its derivative. The utility of zinc chloride over other catalysts such as zinc dust and zinc acetate exhibits a 49–87% yield of carbamates. American Chemical Society 2022-09-26 /pmc/articles/PMC9557893/ /pubmed/36249350 http://dx.doi.org/10.1021/acsomega.2c05350 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Gayke, Manoj
Hirapara, Nirbhay
Narode, Hanuman
Bhosle, Siddhanath D.
Bhosale, Rajesh S.
Yadav, Jhillu Singh
Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine
title Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine
title_full Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine
title_fullStr Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine
title_full_unstemmed Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine
title_short Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine
title_sort zinc chloride-catalyzed synthesis of carbamates: an application for the synthesis of the anti-alzheimer’s drug rivastigmine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557893/
https://www.ncbi.nlm.nih.gov/pubmed/36249350
http://dx.doi.org/10.1021/acsomega.2c05350
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