MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling

Pathogenic Th17 cells drive autoimmune pathology, but the molecular mechanisms underlying Th17 pathogenicity remain poorly understood. Here, we have shown that miR-181a-5p was significantly decreased in pathogenic Th17 cells, and it negatively regulated pathogenic Th17 cell responses in vitro and in...

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Detalles Bibliográficos
Autores principales: Chen, Sisi, Ma, Binyun, Li, Xue, Zhang, Kailang, Wei, Yankai, Du, Bei, Liu, Xun, Wei, Ruihua, Li, Xiaorong, Nian, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557906/
https://www.ncbi.nlm.nih.gov/pubmed/36248732
http://dx.doi.org/10.1016/j.isci.2022.105176

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