Cargando…

Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has a poor prognosis; therefore, early detection is essential. In Japan, more than 90% of esophageal cancers are ESCC. Endoscopy is effective to detect ESCC in the early stage, but there is a limited number of reports examining its efficacy and e...

Descripción completa

Detalles Bibliográficos
Autores principales: Nezu, Yasuko, Manabe, Noriaki, Yoda, Yoshioki, Haruma, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557950/
https://www.ncbi.nlm.nih.gov/pubmed/35976761
http://dx.doi.org/10.1002/ueg2.12284
_version_ 1784807341261062144
author Nezu, Yasuko
Manabe, Noriaki
Yoda, Yoshioki
Haruma, Ken
author_facet Nezu, Yasuko
Manabe, Noriaki
Yoda, Yoshioki
Haruma, Ken
author_sort Nezu, Yasuko
collection PubMed
description BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has a poor prognosis; therefore, early detection is essential. In Japan, more than 90% of esophageal cancers are ESCC. Endoscopy is effective to detect ESCC in the early stage, but there is a limited number of reports examining its efficacy and effectiveness. OBJECTIVE: This study aimed to evaluate the efficacy of screening endoscopy for detecting ESCC. METHODS: This retrospective study analyzed the prevalence of ESCC, annual transition of prevalence, and the stage of each ESCC among 128,520 medical check‐up patients who underwent esophagogastroduodenoscopy from April 2015 to March 2020 at Yamanashi Koseiren Health Care Center. Furthermore, a case‐control study utilized the multivariate logistic regression analysis was performed to assess the risk factor of ESCC. RESULTS: Among a total of 128,520 subjects, 42 ESCC patients were detected, with 95.2% being diagnosed at early stages. Annual prevalence in males was 0.015% (2/13,122) in 2015, 0.044% (6/13,562) in 2016, 0.044% (6/13,676) in 2017, 0.074% (10/13,488) in 2018%, and 0.11% (16/14,386) in 2019. ESCC prevalence has been increasing each year. A significant increase was observed between 2015 and 2018 (p = 0.039). ESCC prevalence was 0.102% (25/24,272) when focusing on males aged over 50 years with a history of smoking and drinking. Regarding the case‐control study, the multivariate logistic regression analysis revealed smoking (p = 0.044), mean corpuscular volume (MCV) (p = 0.0018), and severe gastric atrophy (p = 0.048) as positively correlated with ESCC. CONCLUSION: In conclusion, ESCC has been increasing in our center from 2015 to 2019, and the prevalence has been approaching that of gastric cancer in 2019 in male subjects. ESCC can be detected efficiently by targeting males with high MCV who have a history of drinking and smoking.
format Online
Article
Text
id pubmed-9557950
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-95579502022-10-16 Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males Nezu, Yasuko Manabe, Noriaki Yoda, Yoshioki Haruma, Ken United European Gastroenterol J Endoscopy BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has a poor prognosis; therefore, early detection is essential. In Japan, more than 90% of esophageal cancers are ESCC. Endoscopy is effective to detect ESCC in the early stage, but there is a limited number of reports examining its efficacy and effectiveness. OBJECTIVE: This study aimed to evaluate the efficacy of screening endoscopy for detecting ESCC. METHODS: This retrospective study analyzed the prevalence of ESCC, annual transition of prevalence, and the stage of each ESCC among 128,520 medical check‐up patients who underwent esophagogastroduodenoscopy from April 2015 to March 2020 at Yamanashi Koseiren Health Care Center. Furthermore, a case‐control study utilized the multivariate logistic regression analysis was performed to assess the risk factor of ESCC. RESULTS: Among a total of 128,520 subjects, 42 ESCC patients were detected, with 95.2% being diagnosed at early stages. Annual prevalence in males was 0.015% (2/13,122) in 2015, 0.044% (6/13,562) in 2016, 0.044% (6/13,676) in 2017, 0.074% (10/13,488) in 2018%, and 0.11% (16/14,386) in 2019. ESCC prevalence has been increasing each year. A significant increase was observed between 2015 and 2018 (p = 0.039). ESCC prevalence was 0.102% (25/24,272) when focusing on males aged over 50 years with a history of smoking and drinking. Regarding the case‐control study, the multivariate logistic regression analysis revealed smoking (p = 0.044), mean corpuscular volume (MCV) (p = 0.0018), and severe gastric atrophy (p = 0.048) as positively correlated with ESCC. CONCLUSION: In conclusion, ESCC has been increasing in our center from 2015 to 2019, and the prevalence has been approaching that of gastric cancer in 2019 in male subjects. ESCC can be detected efficiently by targeting males with high MCV who have a history of drinking and smoking. John Wiley and Sons Inc. 2022-08-17 /pmc/articles/PMC9557950/ /pubmed/35976761 http://dx.doi.org/10.1002/ueg2.12284 Text en © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Endoscopy
Nezu, Yasuko
Manabe, Noriaki
Yoda, Yoshioki
Haruma, Ken
Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males
title Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males
title_full Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males
title_fullStr Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males
title_full_unstemmed Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males
title_short Effectiveness of screening endoscopy for esophageal squamous cell carcinoma in Japanese males
title_sort effectiveness of screening endoscopy for esophageal squamous cell carcinoma in japanese males
topic Endoscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557950/
https://www.ncbi.nlm.nih.gov/pubmed/35976761
http://dx.doi.org/10.1002/ueg2.12284
work_keys_str_mv AT nezuyasuko effectivenessofscreeningendoscopyforesophagealsquamouscellcarcinomainjapanesemales
AT manabenoriaki effectivenessofscreeningendoscopyforesophagealsquamouscellcarcinomainjapanesemales
AT yodayoshioki effectivenessofscreeningendoscopyforesophagealsquamouscellcarcinomainjapanesemales
AT harumaken effectivenessofscreeningendoscopyforesophagealsquamouscellcarcinomainjapanesemales