Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms

Many eukaryotic protein kinases are activated by the intramolecular autophosphorylation of activation loop residues. Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in yeast that autophosphorylates its activation loop tyrosine and thereby upregulates catalytic output. This reactio...

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Detalles Bibliográficos
Autores principales: Rimal, Abhimannyu, Swayne, Thomas M., Kamdar, Zeal P., Tewey, Madison A., Winter, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558048/
https://www.ncbi.nlm.nih.gov/pubmed/36063999
http://dx.doi.org/10.1016/j.jbc.2022.102450

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