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The structure of sensory afferent compartments in health and disease

Primary sensory neurons are a heterogeneous population of cells able to respond to both innocuous and noxious stimuli. Like most neurons they are highly compartmentalised, allowing them to detect, convey and transfer sensory information. These compartments include specialised sensory endings in the...

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Autores principales: Middleton, Steven J., Perez‐Sanchez, Jimena, Dawes, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558153/
https://www.ncbi.nlm.nih.gov/pubmed/34528255
http://dx.doi.org/10.1111/joa.13544
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author Middleton, Steven J.
Perez‐Sanchez, Jimena
Dawes, John M.
author_facet Middleton, Steven J.
Perez‐Sanchez, Jimena
Dawes, John M.
author_sort Middleton, Steven J.
collection PubMed
description Primary sensory neurons are a heterogeneous population of cells able to respond to both innocuous and noxious stimuli. Like most neurons they are highly compartmentalised, allowing them to detect, convey and transfer sensory information. These compartments include specialised sensory endings in the skin, the nodes of Ranvier in myelinated axons, the cell soma and their central terminals in the spinal cord. In this review, we will highlight the importance of these compartments to primary afferent function, describe how these structures are compromised following nerve damage and how this relates to neuropathic pain.
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spelling pubmed-95581532022-10-16 The structure of sensory afferent compartments in health and disease Middleton, Steven J. Perez‐Sanchez, Jimena Dawes, John M. J Anat Review Article Primary sensory neurons are a heterogeneous population of cells able to respond to both innocuous and noxious stimuli. Like most neurons they are highly compartmentalised, allowing them to detect, convey and transfer sensory information. These compartments include specialised sensory endings in the skin, the nodes of Ranvier in myelinated axons, the cell soma and their central terminals in the spinal cord. In this review, we will highlight the importance of these compartments to primary afferent function, describe how these structures are compromised following nerve damage and how this relates to neuropathic pain. John Wiley and Sons Inc. 2021-09-15 2022-11 /pmc/articles/PMC9558153/ /pubmed/34528255 http://dx.doi.org/10.1111/joa.13544 Text en © 2021 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Middleton, Steven J.
Perez‐Sanchez, Jimena
Dawes, John M.
The structure of sensory afferent compartments in health and disease
title The structure of sensory afferent compartments in health and disease
title_full The structure of sensory afferent compartments in health and disease
title_fullStr The structure of sensory afferent compartments in health and disease
title_full_unstemmed The structure of sensory afferent compartments in health and disease
title_short The structure of sensory afferent compartments in health and disease
title_sort structure of sensory afferent compartments in health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558153/
https://www.ncbi.nlm.nih.gov/pubmed/34528255
http://dx.doi.org/10.1111/joa.13544
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