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Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms

Chagas disease is a parasitic disease from South America, affecting around 7 million people worldwide. Decades after the infection, 30% of people develop chronic forms, including Chronic Chagas Cardiomyopathy (CCC), for which no treatment exists. Two stages characterized this form: the moderate form...

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Autores principales: Brochet, Pauline, Ianni, Barbara, Nunes, João P. S., Frade, Amanda F., Teixeira, Priscila C., Mady, Charles, Ferreira, Ludmila R. P., Kuramoto, Andreia, Pissetti, Cristina W., Saba, Bruno, Cândido, Darlan D. S., Dias, Fabrício, Sampaio, Marcelo, Marin-Neto, José A., Fragata, Abílio, Zaniratto, Ricardo C .F., Siqueira, Sergio, Peixoto, Giselle D. L., Rigaud, Vagner O. C., Buck, Paula, Almeida, Rafael R., Lin-Wang, Hui Tzu, Schmidt, André, Martinelli, Martino, Hirata, Mario H., Donadi, Eduardo, Rodrigues Junior, Virmondes, Pereira, Alexandre C., Kalil, Jorge, Spinelli, Lionel, Cunha-Neto, Edecio, Chevillard, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558220/
https://www.ncbi.nlm.nih.gov/pubmed/36248819
http://dx.doi.org/10.3389/fimmu.2022.1020572
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author Brochet, Pauline
Ianni, Barbara
Nunes, João P. S.
Frade, Amanda F.
Teixeira, Priscila C.
Mady, Charles
Ferreira, Ludmila R. P.
Kuramoto, Andreia
Pissetti, Cristina W.
Saba, Bruno
Cândido, Darlan D. S.
Dias, Fabrício
Sampaio, Marcelo
Marin-Neto, José A.
Fragata, Abílio
Zaniratto, Ricardo C .F.
Siqueira, Sergio
Peixoto, Giselle D. L.
Rigaud, Vagner O. C.
Buck, Paula
Almeida, Rafael R.
Lin-Wang, Hui Tzu
Schmidt, André
Martinelli, Martino
Hirata, Mario H.
Donadi, Eduardo
Rodrigues Junior, Virmondes
Pereira, Alexandre C.
Kalil, Jorge
Spinelli, Lionel
Cunha-Neto, Edecio
Chevillard, Christophe
author_facet Brochet, Pauline
Ianni, Barbara
Nunes, João P. S.
Frade, Amanda F.
Teixeira, Priscila C.
Mady, Charles
Ferreira, Ludmila R. P.
Kuramoto, Andreia
Pissetti, Cristina W.
Saba, Bruno
Cândido, Darlan D. S.
Dias, Fabrício
Sampaio, Marcelo
Marin-Neto, José A.
Fragata, Abílio
Zaniratto, Ricardo C .F.
Siqueira, Sergio
Peixoto, Giselle D. L.
Rigaud, Vagner O. C.
Buck, Paula
Almeida, Rafael R.
Lin-Wang, Hui Tzu
Schmidt, André
Martinelli, Martino
Hirata, Mario H.
Donadi, Eduardo
Rodrigues Junior, Virmondes
Pereira, Alexandre C.
Kalil, Jorge
Spinelli, Lionel
Cunha-Neto, Edecio
Chevillard, Christophe
author_sort Brochet, Pauline
collection PubMed
description Chagas disease is a parasitic disease from South America, affecting around 7 million people worldwide. Decades after the infection, 30% of people develop chronic forms, including Chronic Chagas Cardiomyopathy (CCC), for which no treatment exists. Two stages characterized this form: the moderate form, characterized by a heart ejection fraction (EF) ≥ 0.4, and the severe form, associated to an EF < 0.4. We propose two sets of DNA methylation biomarkers which can predict in blood CCC occurrence, and CCC stage. This analysis, based on machine learning algorithms, makes predictions with more than 95% accuracy in a test cohort. Beyond their predictive capacity, these CpGs are located near genes involved in the immune response, the nervous system, ion transport or ATP synthesis, pathways known to be deregulated in CCCs. Among these genes, some are also differentially expressed in heart tissues. Interestingly, the CpGs of interest are tagged to genes mainly involved in nervous and ionic processes. Given the close link between methylation and gene expression, these lists of CpGs promise to be not only good biomarkers, but also good indicators of key elements in the development of this pathology.
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spelling pubmed-95582202022-10-14 Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms Brochet, Pauline Ianni, Barbara Nunes, João P. S. Frade, Amanda F. Teixeira, Priscila C. Mady, Charles Ferreira, Ludmila R. P. Kuramoto, Andreia Pissetti, Cristina W. Saba, Bruno Cândido, Darlan D. S. Dias, Fabrício Sampaio, Marcelo Marin-Neto, José A. Fragata, Abílio Zaniratto, Ricardo C .F. Siqueira, Sergio Peixoto, Giselle D. L. Rigaud, Vagner O. C. Buck, Paula Almeida, Rafael R. Lin-Wang, Hui Tzu Schmidt, André Martinelli, Martino Hirata, Mario H. Donadi, Eduardo Rodrigues Junior, Virmondes Pereira, Alexandre C. Kalil, Jorge Spinelli, Lionel Cunha-Neto, Edecio Chevillard, Christophe Front Immunol Immunology Chagas disease is a parasitic disease from South America, affecting around 7 million people worldwide. Decades after the infection, 30% of people develop chronic forms, including Chronic Chagas Cardiomyopathy (CCC), for which no treatment exists. Two stages characterized this form: the moderate form, characterized by a heart ejection fraction (EF) ≥ 0.4, and the severe form, associated to an EF < 0.4. We propose two sets of DNA methylation biomarkers which can predict in blood CCC occurrence, and CCC stage. This analysis, based on machine learning algorithms, makes predictions with more than 95% accuracy in a test cohort. Beyond their predictive capacity, these CpGs are located near genes involved in the immune response, the nervous system, ion transport or ATP synthesis, pathways known to be deregulated in CCCs. Among these genes, some are also differentially expressed in heart tissues. Interestingly, the CpGs of interest are tagged to genes mainly involved in nervous and ionic processes. Given the close link between methylation and gene expression, these lists of CpGs promise to be not only good biomarkers, but also good indicators of key elements in the development of this pathology. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9558220/ /pubmed/36248819 http://dx.doi.org/10.3389/fimmu.2022.1020572 Text en Copyright © 2022 Brochet, Ianni, Nunes, Frade, Teixeira, Mady, Ferreira, Kuramoto, Pissetti, Saba, Cândido, Dias, Sampaio, Marin-Neto, Fragata, Zaniratto, Siqueira, Peixoto, Rigaud, Buck, Almeida, Lin-Wang, Schmidt, Martinelli, Hirata, Donadi, Rodrigues Junior, Pereira, Kalil, Spinelli, Cunha-Neto and Chevillard https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Brochet, Pauline
Ianni, Barbara
Nunes, João P. S.
Frade, Amanda F.
Teixeira, Priscila C.
Mady, Charles
Ferreira, Ludmila R. P.
Kuramoto, Andreia
Pissetti, Cristina W.
Saba, Bruno
Cândido, Darlan D. S.
Dias, Fabrício
Sampaio, Marcelo
Marin-Neto, José A.
Fragata, Abílio
Zaniratto, Ricardo C .F.
Siqueira, Sergio
Peixoto, Giselle D. L.
Rigaud, Vagner O. C.
Buck, Paula
Almeida, Rafael R.
Lin-Wang, Hui Tzu
Schmidt, André
Martinelli, Martino
Hirata, Mario H.
Donadi, Eduardo
Rodrigues Junior, Virmondes
Pereira, Alexandre C.
Kalil, Jorge
Spinelli, Lionel
Cunha-Neto, Edecio
Chevillard, Christophe
Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
title Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
title_full Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
title_fullStr Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
title_full_unstemmed Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
title_short Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
title_sort blood dna methylation marks discriminate chagas cardiomyopathy disease clinical forms
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558220/
https://www.ncbi.nlm.nih.gov/pubmed/36248819
http://dx.doi.org/10.3389/fimmu.2022.1020572
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