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A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk

Objective: A meta-analysis is used to explore the relationship between polycystic ovary syndrome (PCOS) and the risk of Sleep disturbances. Method: Cochrane Library, PubMed, Embase, and Web of Science databases are searched by computer from their establishment to 1 May 2022. Review Manager 5.4 softw...

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Autores principales: Wang, Chaoyu, Huang, Tao, Song, Wu, Zhu, Jinru, Liu, Yanhong, Chen, Xiaojuan, Sun, Xishi, Wu, Qinglan, Chen, Huimin, Liao, Huizhao, Lin, Junyan, Ou, Xudong, Zou, Zhihong, Wang, Zhiwei, Zheng, Zhenzhen, Wu, Kang, Chen, Riken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558285/
https://www.ncbi.nlm.nih.gov/pubmed/36246113
http://dx.doi.org/10.3389/fphys.2022.957112
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author Wang, Chaoyu
Huang, Tao
Song, Wu
Zhu, Jinru
Liu, Yanhong
Chen, Xiaojuan
Sun, Xishi
Wu, Qinglan
Chen, Huimin
Liao, Huizhao
Lin, Junyan
Ou, Xudong
Zou, Zhihong
Wang, Zhiwei
Zheng, Zhenzhen
Wu, Kang
Chen, Riken
author_facet Wang, Chaoyu
Huang, Tao
Song, Wu
Zhu, Jinru
Liu, Yanhong
Chen, Xiaojuan
Sun, Xishi
Wu, Qinglan
Chen, Huimin
Liao, Huizhao
Lin, Junyan
Ou, Xudong
Zou, Zhihong
Wang, Zhiwei
Zheng, Zhenzhen
Wu, Kang
Chen, Riken
author_sort Wang, Chaoyu
collection PubMed
description Objective: A meta-analysis is used to explore the relationship between polycystic ovary syndrome (PCOS) and the risk of Sleep disturbances. Method: Cochrane Library, PubMed, Embase, and Web of Science databases are searched by computer from their establishment to 1 May 2022. Review Manager 5.4 software is used for the meta-analysis. Results: A total of nine articles are included, with 1,107 subjects. The results show that PCOS is positively associated with the risk of Sleep disturbances. Comparing with the “PCOS group” (experimental group) with the “NON-PCOS group” (control group), the incidence of Sleep disturbances is higher (OR = 11.24, 95% CI: 2.00–63.10, Z = 2.75, p = 0.006); the Pittsburgh Sleep Quality Index (PSQI) scores of the PCOS group is higher than that of the NON-PCOS group (MD = 0.78, 95% CI: 0.32–1.25, Z = 3.30, p = 0.001); the Epworth Sleepiness Scale (ESS) scores of the PCOS group is higher than that of the NON-PCOS group (MD = 2.49, 95% CI: 0.80–4.18, Z = 2.88, p = 0.004); Apnea hypopnea index (AHIs) in the PCOS group are higher than those in the NON-PCOS group (MD = 2.68, 95% CI: 1.07–4.28, Z = 3.27, p = 0.001); the sleep efficiency of the PCOS group is lower than that of the NON-PCOS group (MD = -5.16, 95% CI: 9.39–-0.93, Z = 2.39, p = 0.02); the sleep onset latency of the PCOS group is higher than that of the NON-PCOS group (MD = 2.45, 95% CI: 1.40–3.50, Z = 4.57, p < 0.001); and the Rapid Eyes Movement (REM) sleep in the PCOS group is higher than that in the NON-PCOS group (MD = 17.19, 95% CI: 11.62–55.76, Z = 6.05, p < 0.001). The studies included in each analysis have publication biases of different sizes. After subgroup analysis and sensitivity analysis, the heterogeneity of each study in the meta-analysis is reduced, the bias is reduced accordingly, and the stability of the results can be maintained. Conclusion: PCOS is positively associated with the risk of Sleep disturbances. In order to reduce such risk, attention should be paid to the role of PCOS management, and PCOS prevention and treatment should be actively carried out.
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spelling pubmed-95582852022-10-14 A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk Wang, Chaoyu Huang, Tao Song, Wu Zhu, Jinru Liu, Yanhong Chen, Xiaojuan Sun, Xishi Wu, Qinglan Chen, Huimin Liao, Huizhao Lin, Junyan Ou, Xudong Zou, Zhihong Wang, Zhiwei Zheng, Zhenzhen Wu, Kang Chen, Riken Front Physiol Physiology Objective: A meta-analysis is used to explore the relationship between polycystic ovary syndrome (PCOS) and the risk of Sleep disturbances. Method: Cochrane Library, PubMed, Embase, and Web of Science databases are searched by computer from their establishment to 1 May 2022. Review Manager 5.4 software is used for the meta-analysis. Results: A total of nine articles are included, with 1,107 subjects. The results show that PCOS is positively associated with the risk of Sleep disturbances. Comparing with the “PCOS group” (experimental group) with the “NON-PCOS group” (control group), the incidence of Sleep disturbances is higher (OR = 11.24, 95% CI: 2.00–63.10, Z = 2.75, p = 0.006); the Pittsburgh Sleep Quality Index (PSQI) scores of the PCOS group is higher than that of the NON-PCOS group (MD = 0.78, 95% CI: 0.32–1.25, Z = 3.30, p = 0.001); the Epworth Sleepiness Scale (ESS) scores of the PCOS group is higher than that of the NON-PCOS group (MD = 2.49, 95% CI: 0.80–4.18, Z = 2.88, p = 0.004); Apnea hypopnea index (AHIs) in the PCOS group are higher than those in the NON-PCOS group (MD = 2.68, 95% CI: 1.07–4.28, Z = 3.27, p = 0.001); the sleep efficiency of the PCOS group is lower than that of the NON-PCOS group (MD = -5.16, 95% CI: 9.39–-0.93, Z = 2.39, p = 0.02); the sleep onset latency of the PCOS group is higher than that of the NON-PCOS group (MD = 2.45, 95% CI: 1.40–3.50, Z = 4.57, p < 0.001); and the Rapid Eyes Movement (REM) sleep in the PCOS group is higher than that in the NON-PCOS group (MD = 17.19, 95% CI: 11.62–55.76, Z = 6.05, p < 0.001). The studies included in each analysis have publication biases of different sizes. After subgroup analysis and sensitivity analysis, the heterogeneity of each study in the meta-analysis is reduced, the bias is reduced accordingly, and the stability of the results can be maintained. Conclusion: PCOS is positively associated with the risk of Sleep disturbances. In order to reduce such risk, attention should be paid to the role of PCOS management, and PCOS prevention and treatment should be actively carried out. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9558285/ /pubmed/36246113 http://dx.doi.org/10.3389/fphys.2022.957112 Text en Copyright © 2022 Wang, Huang, Song, Zhu, Liu, Chen, Sun, Wu, Chen, Liao, Lin, Ou, Zou, Wang, Zheng, Wu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Chaoyu
Huang, Tao
Song, Wu
Zhu, Jinru
Liu, Yanhong
Chen, Xiaojuan
Sun, Xishi
Wu, Qinglan
Chen, Huimin
Liao, Huizhao
Lin, Junyan
Ou, Xudong
Zou, Zhihong
Wang, Zhiwei
Zheng, Zhenzhen
Wu, Kang
Chen, Riken
A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
title A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
title_full A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
title_fullStr A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
title_full_unstemmed A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
title_short A meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
title_sort meta-analysis of the relationship between polycystic ovary syndrome and sleep disturbances risk
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558285/
https://www.ncbi.nlm.nih.gov/pubmed/36246113
http://dx.doi.org/10.3389/fphys.2022.957112
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