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Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients

Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed...

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Autores principales: YOOK, Hwa Jung, SON, Joon Ho, KIM, Yeong Ho, HAN, Ju Hee, LEE, Ji Hyun, PARK, Young Min, CHUNG, Nack-Gyun, KIM, Hee Je, BANG, Chul Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558330/
https://www.ncbi.nlm.nih.gov/pubmed/35088871
http://dx.doi.org/10.2340/actadv.v102.1123
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author YOOK, Hwa Jung
SON, Joon Ho
KIM, Yeong Ho
HAN, Ju Hee
LEE, Ji Hyun
PARK, Young Min
CHUNG, Nack-Gyun
KIM, Hee Je
BANG, Chul Hwan
author_facet YOOK, Hwa Jung
SON, Joon Ho
KIM, Yeong Ho
HAN, Ju Hee
LEE, Ji Hyun
PARK, Young Min
CHUNG, Nack-Gyun
KIM, Hee Je
BANG, Chul Hwan
author_sort YOOK, Hwa Jung
collection PubMed
description Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed with leukaemia cutis in the dermatology department of Seoul St Mary’s Hospital between January 2012 and April 2021. Fifty-six cases with cutaneous leukaemic involvement and underlying haematological malignancy were included (40 acute myelogenous leukaemia, 8 acute lymphoblastic leukaemia, 3 chronic myeloid leukaemia, 2 chronic lymphocytic leukaemia, and 3 myelodysplastic syndrome). Male-female ratio 1.9:1, mean age at diagnosis 45.8 years. Plaques (28%) and papules (27%) were the most common skin lesions, followed by patches (18%) and nodules (16%). Mean time from diagnosis of leukaemia to development of leukaemia cutis was 12.3 months. Forty-six patients (84%) died during the 7-year follow-up; mean time from diagnosis of leukaemia cutis to death was 5.4 months. The results suggest that leukaemia cutis is associated with poor outcomes in patients with leukaemia. Comprehensive skin examination of these patients may help diagnose leukaemia cutis early, enabling prompt treatment.
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spelling pubmed-95583302022-10-20 Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients YOOK, Hwa Jung SON, Joon Ho KIM, Yeong Ho HAN, Ju Hee LEE, Ji Hyun PARK, Young Min CHUNG, Nack-Gyun KIM, Hee Je BANG, Chul Hwan Acta Derm Venereol Original Article Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed with leukaemia cutis in the dermatology department of Seoul St Mary’s Hospital between January 2012 and April 2021. Fifty-six cases with cutaneous leukaemic involvement and underlying haematological malignancy were included (40 acute myelogenous leukaemia, 8 acute lymphoblastic leukaemia, 3 chronic myeloid leukaemia, 2 chronic lymphocytic leukaemia, and 3 myelodysplastic syndrome). Male-female ratio 1.9:1, mean age at diagnosis 45.8 years. Plaques (28%) and papules (27%) were the most common skin lesions, followed by patches (18%) and nodules (16%). Mean time from diagnosis of leukaemia to development of leukaemia cutis was 12.3 months. Forty-six patients (84%) died during the 7-year follow-up; mean time from diagnosis of leukaemia cutis to death was 5.4 months. The results suggest that leukaemia cutis is associated with poor outcomes in patients with leukaemia. Comprehensive skin examination of these patients may help diagnose leukaemia cutis early, enabling prompt treatment. Society for Publication of Acta Dermato-Venereologica 2022-02-11 /pmc/articles/PMC9558330/ /pubmed/35088871 http://dx.doi.org/10.2340/actadv.v102.1123 Text en © 2022 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Original Article
YOOK, Hwa Jung
SON, Joon Ho
KIM, Yeong Ho
HAN, Ju Hee
LEE, Ji Hyun
PARK, Young Min
CHUNG, Nack-Gyun
KIM, Hee Je
BANG, Chul Hwan
Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
title Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
title_full Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
title_fullStr Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
title_full_unstemmed Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
title_short Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
title_sort leukaemia cutis: clinical features and outcomes of 56 patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558330/
https://www.ncbi.nlm.nih.gov/pubmed/35088871
http://dx.doi.org/10.2340/actadv.v102.1123
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