Cargando…

Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients

Electrical impedance spectroscopy has clinical relevance in diagnosing malignancy in melanocytic lesions. Sixty-eight lesions with changes during digital follow-up of patients at very high risk of developing melanoma were prospectively included in this study from February to December 2016. Electrica...

Descripción completa

Detalles Bibliográficos
Autores principales: CHAVEZ-BOURGEOIS, Marion, RIBERO, Simone, BARREIRO, Alicia, ESPINOSA, Natalia, CARRERA, Cristina, GARCIA, Adriana, ALOS, Llucia, PUIG, Susana, MALVEHY, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558334/
https://www.ncbi.nlm.nih.gov/pubmed/35535641
http://dx.doi.org/10.2340/actadv.v102.1105
_version_ 1784807420836446208
author CHAVEZ-BOURGEOIS, Marion
RIBERO, Simone
BARREIRO, Alicia
ESPINOSA, Natalia
CARRERA, Cristina
GARCIA, Adriana
ALOS, Llucia
PUIG, Susana
MALVEHY, Josep
author_facet CHAVEZ-BOURGEOIS, Marion
RIBERO, Simone
BARREIRO, Alicia
ESPINOSA, Natalia
CARRERA, Cristina
GARCIA, Adriana
ALOS, Llucia
PUIG, Susana
MALVEHY, Josep
author_sort CHAVEZ-BOURGEOIS, Marion
collection PubMed
description Electrical impedance spectroscopy has clinical relevance in diagnosing malignancy in melanocytic lesions. Sixty-eight lesions with changes during digital follow-up of patients at very high risk of developing melanoma were prospectively included in this study from February to December 2016. Electrical impedance spectroscopy and reflectance confocal microscopy were performed to evaluate their performance in this subset of difficult lesions. Forty-six lesions were considered suspicious on reflectance confocal microscopy and were excised, of these, 19 were diagnosed as melanoma. Fifteen melanomas were detected by electrical impedance spectroscopy, while 4 received a score lower than 4, which suggested no malignancy. The addition of reflectance confocal microscopy improves accuracy while maintaining the same sensitivity. In the case of electrical impedance spectroscopy scores <4, lesions exhibiting changes in follow-up may need short-term monitoring or excision if dermoscopy shows criteria for melanoma. Results of electrical impedance spectroscopy in this subset of very early lesions should be carefully considered due to the risk of false negatives.
format Online
Article
Text
id pubmed-9558334
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Society for Publication of Acta Dermato-Venereologica
record_format MEDLINE/PubMed
spelling pubmed-95583342022-10-20 Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients CHAVEZ-BOURGEOIS, Marion RIBERO, Simone BARREIRO, Alicia ESPINOSA, Natalia CARRERA, Cristina GARCIA, Adriana ALOS, Llucia PUIG, Susana MALVEHY, Josep Acta Derm Venereol Original Article Electrical impedance spectroscopy has clinical relevance in diagnosing malignancy in melanocytic lesions. Sixty-eight lesions with changes during digital follow-up of patients at very high risk of developing melanoma were prospectively included in this study from February to December 2016. Electrical impedance spectroscopy and reflectance confocal microscopy were performed to evaluate their performance in this subset of difficult lesions. Forty-six lesions were considered suspicious on reflectance confocal microscopy and were excised, of these, 19 were diagnosed as melanoma. Fifteen melanomas were detected by electrical impedance spectroscopy, while 4 received a score lower than 4, which suggested no malignancy. The addition of reflectance confocal microscopy improves accuracy while maintaining the same sensitivity. In the case of electrical impedance spectroscopy scores <4, lesions exhibiting changes in follow-up may need short-term monitoring or excision if dermoscopy shows criteria for melanoma. Results of electrical impedance spectroscopy in this subset of very early lesions should be carefully considered due to the risk of false negatives. Society for Publication of Acta Dermato-Venereologica 2022-07-26 /pmc/articles/PMC9558334/ /pubmed/35535641 http://dx.doi.org/10.2340/actadv.v102.1105 Text en © 2022 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Original Article
CHAVEZ-BOURGEOIS, Marion
RIBERO, Simone
BARREIRO, Alicia
ESPINOSA, Natalia
CARRERA, Cristina
GARCIA, Adriana
ALOS, Llucia
PUIG, Susana
MALVEHY, Josep
Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients
title Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients
title_full Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients
title_fullStr Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients
title_full_unstemmed Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients
title_short Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients
title_sort reflectance confocal microscopy and electrical impedance spectroscopy in the early detection of melanoma in changing lesions during long-term follow-up of very high-risk patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558334/
https://www.ncbi.nlm.nih.gov/pubmed/35535641
http://dx.doi.org/10.2340/actadv.v102.1105
work_keys_str_mv AT chavezbourgeoismarion reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT riberosimone reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT barreiroalicia reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT espinosanatalia reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT carreracristina reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT garciaadriana reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT alosllucia reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT puigsusana reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients
AT malvehyjosep reflectanceconfocalmicroscopyandelectricalimpedancespectroscopyintheearlydetectionofmelanomainchanginglesionsduringlongtermfollowupofveryhighriskpatients