The Wnt/β-catenin signalling pathway in Haematological Neoplasms

Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt...

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Autores principales: Yu, Siwei, Han, Ruyue, Gan, Runliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558365/
https://www.ncbi.nlm.nih.gov/pubmed/36224652
http://dx.doi.org/10.1186/s40364-022-00418-9
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author Yu, Siwei
Han, Ruyue
Gan, Runliang
author_facet Yu, Siwei
Han, Ruyue
Gan, Runliang
author_sort Yu, Siwei
collection PubMed
description Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt signalling pathway. The Wnt/β-catenin signalling pathway is highly conserved evolutionarily, and activation or inhibition of either of the pathways may lead to cancer development and progression. The aim of this review is to analyse the mechanisms of action of related molecules in the Wnt/β-catenin pathway in haematologic malignancies and their feasibility as therapeutic targets.
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spelling pubmed-95583652022-10-14 The Wnt/β-catenin signalling pathway in Haematological Neoplasms Yu, Siwei Han, Ruyue Gan, Runliang Biomark Res Review Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt signalling pathway. The Wnt/β-catenin signalling pathway is highly conserved evolutionarily, and activation or inhibition of either of the pathways may lead to cancer development and progression. The aim of this review is to analyse the mechanisms of action of related molecules in the Wnt/β-catenin pathway in haematologic malignancies and their feasibility as therapeutic targets. BioMed Central 2022-10-13 /pmc/articles/PMC9558365/ /pubmed/36224652 http://dx.doi.org/10.1186/s40364-022-00418-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yu, Siwei
Han, Ruyue
Gan, Runliang
The Wnt/β-catenin signalling pathway in Haematological Neoplasms
title The Wnt/β-catenin signalling pathway in Haematological Neoplasms
title_full The Wnt/β-catenin signalling pathway in Haematological Neoplasms
title_fullStr The Wnt/β-catenin signalling pathway in Haematological Neoplasms
title_full_unstemmed The Wnt/β-catenin signalling pathway in Haematological Neoplasms
title_short The Wnt/β-catenin signalling pathway in Haematological Neoplasms
title_sort wnt/β-catenin signalling pathway in haematological neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558365/
https://www.ncbi.nlm.nih.gov/pubmed/36224652
http://dx.doi.org/10.1186/s40364-022-00418-9
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