Why do ‘OFF’ periods still occur during continuous drug delivery in Parkinson’s disease?

Continuous drug delivery (CDD) is used in moderately advanced and late-stage Parkinson’s disease (PD) to control motor and non-motor fluctuations (‘OFF’ periods). Transdermal rotigotine is indicated for early fluctuations, while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel...

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Detalles Bibliográficos
Autores principales: Rota, Silvia, Urso, Daniele, van Wamelen, Daniel J., Leta, Valentina, Boura, Iro, Odin, Per, Espay, Alberto J., Jenner, Peter, Chaudhuri, K. Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558383/
https://www.ncbi.nlm.nih.gov/pubmed/36229860
http://dx.doi.org/10.1186/s40035-022-00317-x

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