A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR)

BACKGROUND: Granulocyte–macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. METHODS: In this randomised, sequential, multicentre, placebo-controlled, double-blind study, adults aged 18–79 years (Part 1)...

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Detalles Bibliográficos
Autores principales: Patel, Jatin, Bass, Damon, Beishuizen, Albertus, Bocca Ruiz, Xavier, Boughanmi, Hatem, Cahn, Anthony, Colombo, Hugo, Criner, Gerard J., Davy, Katherine, de-Miguel-Díez, Javier, Doreski, Pablo A., Fernandes, Sofia, François, Bruno, Gupta, Anubha, Hanrott, Kate, Hatlen, Timothy, Inman, Dave, Isaacs, John D., Jarvis, Emily, Kostina, Natalia, Kropotina, Tatiana, Lacherade, Jean-Claude, Lakshminarayanan, Divya, Martinez-Ayala, Pedro, McEvoy, Charlene, Meziani, Ferhat, Monchi, Mehran, Mukherjee, Sumanta, Muñoz-Bermúdez, Rosana, Neisen, Jessica, O'Shea, Ciara, Plantefeve, Gaëtan, Schifano, Lorrie, Schwab, Lee E., Shahid, Zainab, Shirano, Michinori, Smith, Julia E., Sprinz, Eduardo, Summers, Charlotte, Terzi, Nicolas, Tidswell, Mark A., Trefilova, Yuliya, Williamson, Russell, Wyncoll, Duncan, Layton, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558428/
https://www.ncbi.nlm.nih.gov/pubmed/36229048
http://dx.doi.org/10.1183/13993003.01870-2021

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