Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution

The genome of SARS-CoV-2 encodes for a helicase called nsp13 that is essential for viral replication and highly conserved across related viruses, making it an attractive antiviral target. Here we use nanopore tweezers, a high-resolution single-molecule technique, to gain detailed insight into how ns...

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Detalles Bibliográficos
Autores principales: Marx, Sinduja K., Mickolajczyk, Keith J., Craig, Jonathan M., Thomas, Christopher A., Pfeffer, Akira M., Abell, Sarah J., Carrasco, Jessica D., Franzi, Michaela C., Huang, Jesse R., Kim, Hwanhee C., Brinkerhoff, Henry D., Kapoor, Tarun M., Gundlach, Jens H., Laszlo, Andrew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558434/
https://www.ncbi.nlm.nih.gov/pubmed/36238723
http://dx.doi.org/10.1101/2022.10.07.511351

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