Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a key enzyme involved in the trimming of antigenic peptides presented by Major Histocompatibility Complex class I. It is a target of growing interest for the treatment of autoimmune diseases and in cancer immunotherapy. However, the discovery of pote...

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Detalles Bibliográficos
Autores principales: Camberlein, Virgyl, Fléau, Charlotte, Sierocki, Pierre, Li, Lenong, Gealageas, Ronan, Bosc, Damien, Guillaume, Valentin, Warenghem, Sandrine, Leroux, Florence, Rosell, Melissa, Cheng, Keguang, Medve, Laura, Prigent, Mathilde, Decanter, Myriam, Piveteau, Catherine, Biela, Alexandre, Eveque, Maxime, Dumont, Julie, Mpakali, Anastasia, Giastas, Petros, Herledan, Adrien, Couturier, Cyril, Haupenthal, Jörg, Lesire, Laetitia, Hirsch, Anna K. H., Deprez, Benoit, Stratikos, Efstratios, Bouvier, Marlene, Deprez‐Poulain, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558494/
https://www.ncbi.nlm.nih.gov/pubmed/35904863
http://dx.doi.org/10.1002/anie.202203560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558494/
https://www.ncbi.nlm.nih.gov/pubmed/35904863
http://dx.doi.org/10.1002/anie.202203560

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