Zn(2+)-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase

[Image: see text] Zinc is a cofactor for enzymes involved in DNA replication, peptidoglycan hydrolysis, and pH maintenance, in addition to the transfer of the methyl group to thiols. Here, we discovered a new role of Zn(2+) as an inhibitor for S-adenosyl methionine (SAM) binding in a mycobacterial m...

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Detalles Bibliográficos
Autores principales: Majumdar, Soneya, Gupta, Umang, Chinnasamy, Hariharan V., Laxmipathy, Sathishkumar, Matheshwaran, Saravanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558604/
https://www.ncbi.nlm.nih.gov/pubmed/36249403
http://dx.doi.org/10.1021/acsomega.2c04555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558604/
https://www.ncbi.nlm.nih.gov/pubmed/36249403
http://dx.doi.org/10.1021/acsomega.2c04555

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