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Zn(2+)-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase
[Image: see text] Zinc is a cofactor for enzymes involved in DNA replication, peptidoglycan hydrolysis, and pH maintenance, in addition to the transfer of the methyl group to thiols. Here, we discovered a new role of Zn(2+) as an inhibitor for S-adenosyl methionine (SAM) binding in a mycobacterial m...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558604/ https://www.ncbi.nlm.nih.gov/pubmed/36249403 http://dx.doi.org/10.1021/acsomega.2c04555 |