Cargando…

The role of super-spreaders in modeling of SARS-CoV-2

In stochastic modeling of infectious diseases, it has been established that variations in infectivity affect the probability of a major outbreak, but not the shape of the curves during a major outbreak, which is predicted by deterministic models (Diekmann et al., 2012). However, such conclusions are...

Descripción completa

Detalles Bibliográficos
Autores principales: Rousse, François, Carlsson, Marcus, Ögren, Magnus, Wellander, Benjamin Kalischer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558769/
https://www.ncbi.nlm.nih.gov/pubmed/36267691
http://dx.doi.org/10.1016/j.idm.2022.10.003
_version_ 1784807515388641280
author Rousse, François
Carlsson, Marcus
Ögren, Magnus
Wellander, Benjamin Kalischer
author_facet Rousse, François
Carlsson, Marcus
Ögren, Magnus
Wellander, Benjamin Kalischer
author_sort Rousse, François
collection PubMed
description In stochastic modeling of infectious diseases, it has been established that variations in infectivity affect the probability of a major outbreak, but not the shape of the curves during a major outbreak, which is predicted by deterministic models (Diekmann et al., 2012). However, such conclusions are derived under idealized assumptions such as the population size tending to infinity, and the individual degree of infectivity only depending on variations in the infectiousness period. In this paper we show that the same conclusions hold true in a finite population representing a medium size city, where the degree of infectivity is determined by the offspring distribution, which we try to make as realistic as possible for SARS-CoV-2. In particular, we consider distributions with fat tails, to incorporate the existence of super-spreaders. We also provide new theoretical results on convergence of stochastic models which allows to incorporate any offspring distribution with a finite variance.
format Online
Article
Text
id pubmed-9558769
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher KeAi Publishing
record_format MEDLINE/PubMed
spelling pubmed-95587692022-10-16 The role of super-spreaders in modeling of SARS-CoV-2 Rousse, François Carlsson, Marcus Ögren, Magnus Wellander, Benjamin Kalischer Infect Dis Model Article In stochastic modeling of infectious diseases, it has been established that variations in infectivity affect the probability of a major outbreak, but not the shape of the curves during a major outbreak, which is predicted by deterministic models (Diekmann et al., 2012). However, such conclusions are derived under idealized assumptions such as the population size tending to infinity, and the individual degree of infectivity only depending on variations in the infectiousness period. In this paper we show that the same conclusions hold true in a finite population representing a medium size city, where the degree of infectivity is determined by the offspring distribution, which we try to make as realistic as possible for SARS-CoV-2. In particular, we consider distributions with fat tails, to incorporate the existence of super-spreaders. We also provide new theoretical results on convergence of stochastic models which allows to incorporate any offspring distribution with a finite variance. KeAi Publishing 2022-10-13 /pmc/articles/PMC9558769/ /pubmed/36267691 http://dx.doi.org/10.1016/j.idm.2022.10.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rousse, François
Carlsson, Marcus
Ögren, Magnus
Wellander, Benjamin Kalischer
The role of super-spreaders in modeling of SARS-CoV-2
title The role of super-spreaders in modeling of SARS-CoV-2
title_full The role of super-spreaders in modeling of SARS-CoV-2
title_fullStr The role of super-spreaders in modeling of SARS-CoV-2
title_full_unstemmed The role of super-spreaders in modeling of SARS-CoV-2
title_short The role of super-spreaders in modeling of SARS-CoV-2
title_sort role of super-spreaders in modeling of sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558769/
https://www.ncbi.nlm.nih.gov/pubmed/36267691
http://dx.doi.org/10.1016/j.idm.2022.10.003
work_keys_str_mv AT roussefrancois theroleofsuperspreadersinmodelingofsarscov2
AT carlssonmarcus theroleofsuperspreadersinmodelingofsarscov2
AT ogrenmagnus theroleofsuperspreadersinmodelingofsarscov2
AT wellanderbenjaminkalischer theroleofsuperspreadersinmodelingofsarscov2
AT roussefrancois roleofsuperspreadersinmodelingofsarscov2
AT carlssonmarcus roleofsuperspreadersinmodelingofsarscov2
AT ogrenmagnus roleofsuperspreadersinmodelingofsarscov2
AT wellanderbenjaminkalischer roleofsuperspreadersinmodelingofsarscov2