Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial

INTRODUCTION: HIV self-testing (HIVST) provides a key measure for the early detection of HIV infection in men who have sex with men (MSM). However, dual HIV/syphilis self-testing in the MSM population has not been studied. We describe a randomised controlled trial to evaluate the effect of dual HIV/...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hong, Wang, Min, Zhang, Yun, Tan, Sumin, Huang, Haimei, Zhu, Jiawen, Tian, Weiyi, Mo, Jinli, Mo, Jieling, Cen, Ping, Ning, Chuanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558798/
https://www.ncbi.nlm.nih.gov/pubmed/36216414
http://dx.doi.org/10.1136/bmjopen-2021-059034
_version_ 1784807522449752064
author Zhang, Hong
Wang, Min
Zhang, Yun
Tan, Sumin
Huang, Haimei
Zhu, Jiawen
Tian, Weiyi
Mo, Jinli
Mo, Jieling
Cen, Ping
Ning, Chuanyi
author_facet Zhang, Hong
Wang, Min
Zhang, Yun
Tan, Sumin
Huang, Haimei
Zhu, Jiawen
Tian, Weiyi
Mo, Jinli
Mo, Jieling
Cen, Ping
Ning, Chuanyi
author_sort Zhang, Hong
collection PubMed
description INTRODUCTION: HIV self-testing (HIVST) provides a key measure for the early detection of HIV infection in men who have sex with men (MSM). However, dual HIV/syphilis self-testing in the MSM population has not been studied. We describe a randomised controlled trial to evaluate the effect of dual HIV/syphilis self-testing on the testing frequency among MSM in China. METHODS AND ANALYSIS: This randomised controlled trial will be implemented in Guangxi, China. 330 MSM, including 255 frequent testers and 75 less frequent testers, will be recruited and randomly assigned in a 1:1:1 ratio into one of three arms: a site-based testing arm, a single HIVST arm and a dual HIV/syphilis self-testing arm. Participants in the single HIVST arm and dual HIV/syphilis self-testing arm will receive two free finger-prick-based HIVST or HIV/syphilis self-testing kits at enrolment. The data will be collected at five separate times: baseline, 3 months, 6 months, 9 months and 12 months. The primary outcome is the mean frequency of HIV testing used by MSM after intervention comparing each group during the study period. The secondary outcome includes changes in sex behaviours (eg, number of male sex partners and the proportion of consistent condom use) and the mean number of HIV tests used by the social network members over the study period. ETHICS AND DISSEMINATION: The study protocol was reviewed and approved by the Medical Ethics Committee of Guangxi Medical University, China (20210173). The study results will be disseminated through conferences and academic journals. TRIAL REGISTRATION NUMBER: ChiCTR2100050898.
format Online
Article
Text
id pubmed-9558798
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-95587982022-10-14 Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial Zhang, Hong Wang, Min Zhang, Yun Tan, Sumin Huang, Haimei Zhu, Jiawen Tian, Weiyi Mo, Jinli Mo, Jieling Cen, Ping Ning, Chuanyi BMJ Open HIV/AIDS INTRODUCTION: HIV self-testing (HIVST) provides a key measure for the early detection of HIV infection in men who have sex with men (MSM). However, dual HIV/syphilis self-testing in the MSM population has not been studied. We describe a randomised controlled trial to evaluate the effect of dual HIV/syphilis self-testing on the testing frequency among MSM in China. METHODS AND ANALYSIS: This randomised controlled trial will be implemented in Guangxi, China. 330 MSM, including 255 frequent testers and 75 less frequent testers, will be recruited and randomly assigned in a 1:1:1 ratio into one of three arms: a site-based testing arm, a single HIVST arm and a dual HIV/syphilis self-testing arm. Participants in the single HIVST arm and dual HIV/syphilis self-testing arm will receive two free finger-prick-based HIVST or HIV/syphilis self-testing kits at enrolment. The data will be collected at five separate times: baseline, 3 months, 6 months, 9 months and 12 months. The primary outcome is the mean frequency of HIV testing used by MSM after intervention comparing each group during the study period. The secondary outcome includes changes in sex behaviours (eg, number of male sex partners and the proportion of consistent condom use) and the mean number of HIV tests used by the social network members over the study period. ETHICS AND DISSEMINATION: The study protocol was reviewed and approved by the Medical Ethics Committee of Guangxi Medical University, China (20210173). The study results will be disseminated through conferences and academic journals. TRIAL REGISTRATION NUMBER: ChiCTR2100050898. BMJ Publishing Group 2022-10-10 /pmc/articles/PMC9558798/ /pubmed/36216414 http://dx.doi.org/10.1136/bmjopen-2021-059034 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle HIV/AIDS
Zhang, Hong
Wang, Min
Zhang, Yun
Tan, Sumin
Huang, Haimei
Zhu, Jiawen
Tian, Weiyi
Mo, Jinli
Mo, Jieling
Cen, Ping
Ning, Chuanyi
Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial
title Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial
title_full Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial
title_fullStr Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial
title_full_unstemmed Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial
title_short Usability of dual HIV/syphilis self-testing among men who have sex with men in China: study protocol for a three-arm randomised controlled trial
title_sort usability of dual hiv/syphilis self-testing among men who have sex with men in china: study protocol for a three-arm randomised controlled trial
topic HIV/AIDS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558798/
https://www.ncbi.nlm.nih.gov/pubmed/36216414
http://dx.doi.org/10.1136/bmjopen-2021-059034
work_keys_str_mv AT zhanghong usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT wangmin usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT zhangyun usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT tansumin usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT huanghaimei usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT zhujiawen usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT tianweiyi usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT mojinli usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT mojieling usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT cenping usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial
AT ningchuanyi usabilityofdualhivsyphilisselftestingamongmenwhohavesexwithmeninchinastudyprotocolforathreearmrandomisedcontrolledtrial