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Glycosaminoglycans affect endothelial to mesenchymal transformation, proliferation, and calcification in a 3D model of aortic valve disease

Calcific nodules form in the fibrosa layer of the aortic valve in calcific aortic valve disease (CAVD). Glycosaminoglycans (GAGs), which are normally found in the valve spongiosa, are located local to calcific nodules. Previous work suggests that GAGs induce endothelial to mesenchymal transformation...

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Detalles Bibliográficos
Autores principales:	Bramsen, Jonathan Alejandro, Alber, Bridget R., Mendoza, Melissa, Murray, Bruce T., Chen, Mei-Hsiu, Huang, Peter, Mahler, Gretchen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558823/ https://www.ncbi.nlm.nih.gov/pubmed/36247482 http://dx.doi.org/10.3389/fcvm.2022.975732

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