Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying

Anti-CD19 CAR-T cell immunotherapy is a hopeful treatment option for patients with B cell lymphomas, however it copes with partly severe adverse effects like neurotoxicity. Single-cell resolved molecular data sets in combination with clinical parametrization allow for comprehensive characterization...

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Detalles Bibliográficos
Autores principales: Loeffler-Wirth, Henry, Rade, Michael, Arakelyan, Arsen, Kreuz, Markus, Loeffler, Markus, Koehl, Ulrike, Reiche, Kristin, Binder, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558919/
https://www.ncbi.nlm.nih.gov/pubmed/36248848
http://dx.doi.org/10.3389/fimmu.2022.994885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558919/
https://www.ncbi.nlm.nih.gov/pubmed/36248848
http://dx.doi.org/10.3389/fimmu.2022.994885

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