Cargando…

Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease

PURPOSE: To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition. DESIGN: Cross-sectional. PARTICIPANTS: Patients with a clinical diagnosis of AD, MCI, PD, or normal cogniti...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Justin P., Robbins, Cason B., Stinnett, Sandra S., Johnson, Kim G., Scott, Burton L., Grewal, Dilraj S., Fekrat, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559083/
https://www.ncbi.nlm.nih.gov/pubmed/36246947
http://dx.doi.org/10.1016/j.xops.2021.100075
_version_ 1784807583628918784
author Ma, Justin P.
Robbins, Cason B.
Stinnett, Sandra S.
Johnson, Kim G.
Scott, Burton L.
Grewal, Dilraj S.
Fekrat, Sharon
author_facet Ma, Justin P.
Robbins, Cason B.
Stinnett, Sandra S.
Johnson, Kim G.
Scott, Burton L.
Grewal, Dilraj S.
Fekrat, Sharon
author_sort Ma, Justin P.
collection PubMed
description PURPOSE: To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition. DESIGN: Cross-sectional. PARTICIPANTS: Patients with a clinical diagnosis of AD, MCI, PD, or normal cognition were imaged. Those with glaucoma, diabetes mellitus, vitreoretinal pathology, and poor-quality images were excluded. METHODS: Each eligible eye of each participant underwent 2 OCTA 4.5 × 4.5-mm peripapillary scans in a single session using a Zeiss Cirrus HD-OCT 5000 with AngioPlex (Carl Zeiss Meditec). The Zeiss software (v11.0.0.29946) quantified measures of perfusion in the radial peripapillary capillary (RPC) plexus in 4 sectors (superior, nasal, inferior, temporal). The average of these sectors was calculated and reported. MAIN OUTCOME MEASURES: Radial peripapillary capillary plexus perfusion was quantified using 2 parameters: capillary perfusion density (CPD) and capillary flux index (CFI). Intraclass correlation coefficients (ICCs) were used to quantify repeatability. For subjects who had both eyes included, the average values of each scan pair were used to assess interocular symmetry of CPD and CFI. RESULTS: Of 374 eyes, 46 were from participants who had AD, 85 were from participants who had MCI, 87 were from participants who had PD, and 156 were from participants who had normal cognition. Capillary perfusion density ICC in AD = 0.88 (95% confidence interval [CI], 0.79–0.93), MCI = 0.95 (0.92–0.96), PD = 0.91 (0.87–0.94), and controls = 0.90 (0.87–0.93). Capillary flux index ICC in AD = 0.82 (0.70–0.90), MCI = 0.87 (0.80–0.91), PD = 0.91 (0.87–0.94) and controls = 0.85 (0.79–0.89). There were no significant differences in interocular variation in average CPD and CFI in AD, MCI, or PD (all P > 0.05). Isolated interocular sectoral CPD differences were noted in AD (nasal, P = 0.049; temporal, P = 0.024), PD (nasal, P = 0.036), and controls (nasal, P = 0.016). Interocular differences in CFI in the superior sector in MCI (P = 0.028) and in average CFI for controls (P = 0.035) were observed. CONCLUSIONS: Peripapillary OCTA repeatability in AD, MCI, and PD is good-excellent and similar to those with normal cognition. Insignificant interocular asymmetry in peripapillary OCTA suggests neurodegeneration may proceed uniformly; future studies may reveal the appropriateness of single-eye imaging.
format Online
Article
Text
id pubmed-9559083
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-95590832022-10-14 Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease Ma, Justin P. Robbins, Cason B. Stinnett, Sandra S. Johnson, Kim G. Scott, Burton L. Grewal, Dilraj S. Fekrat, Sharon Ophthalmol Sci Original Article PURPOSE: To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition. DESIGN: Cross-sectional. PARTICIPANTS: Patients with a clinical diagnosis of AD, MCI, PD, or normal cognition were imaged. Those with glaucoma, diabetes mellitus, vitreoretinal pathology, and poor-quality images were excluded. METHODS: Each eligible eye of each participant underwent 2 OCTA 4.5 × 4.5-mm peripapillary scans in a single session using a Zeiss Cirrus HD-OCT 5000 with AngioPlex (Carl Zeiss Meditec). The Zeiss software (v11.0.0.29946) quantified measures of perfusion in the radial peripapillary capillary (RPC) plexus in 4 sectors (superior, nasal, inferior, temporal). The average of these sectors was calculated and reported. MAIN OUTCOME MEASURES: Radial peripapillary capillary plexus perfusion was quantified using 2 parameters: capillary perfusion density (CPD) and capillary flux index (CFI). Intraclass correlation coefficients (ICCs) were used to quantify repeatability. For subjects who had both eyes included, the average values of each scan pair were used to assess interocular symmetry of CPD and CFI. RESULTS: Of 374 eyes, 46 were from participants who had AD, 85 were from participants who had MCI, 87 were from participants who had PD, and 156 were from participants who had normal cognition. Capillary perfusion density ICC in AD = 0.88 (95% confidence interval [CI], 0.79–0.93), MCI = 0.95 (0.92–0.96), PD = 0.91 (0.87–0.94), and controls = 0.90 (0.87–0.93). Capillary flux index ICC in AD = 0.82 (0.70–0.90), MCI = 0.87 (0.80–0.91), PD = 0.91 (0.87–0.94) and controls = 0.85 (0.79–0.89). There were no significant differences in interocular variation in average CPD and CFI in AD, MCI, or PD (all P > 0.05). Isolated interocular sectoral CPD differences were noted in AD (nasal, P = 0.049; temporal, P = 0.024), PD (nasal, P = 0.036), and controls (nasal, P = 0.016). Interocular differences in CFI in the superior sector in MCI (P = 0.028) and in average CFI for controls (P = 0.035) were observed. CONCLUSIONS: Peripapillary OCTA repeatability in AD, MCI, and PD is good-excellent and similar to those with normal cognition. Insignificant interocular asymmetry in peripapillary OCTA suggests neurodegeneration may proceed uniformly; future studies may reveal the appropriateness of single-eye imaging. Elsevier 2021-11-13 /pmc/articles/PMC9559083/ /pubmed/36246947 http://dx.doi.org/10.1016/j.xops.2021.100075 Text en © 2021 by the American Academy of Ophthalmology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ma, Justin P.
Robbins, Cason B.
Stinnett, Sandra S.
Johnson, Kim G.
Scott, Burton L.
Grewal, Dilraj S.
Fekrat, Sharon
Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease
title Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease
title_full Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease
title_fullStr Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease
title_full_unstemmed Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease
title_short Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease
title_sort repeatability of peripapillary oct angiography in neurodegenerative disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559083/
https://www.ncbi.nlm.nih.gov/pubmed/36246947
http://dx.doi.org/10.1016/j.xops.2021.100075
work_keys_str_mv AT majustinp repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease
AT robbinscasonb repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease
AT stinnettsandras repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease
AT johnsonkimg repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease
AT scottburtonl repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease
AT grewaldilrajs repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease
AT fekratsharon repeatabilityofperipapillaryoctangiographyinneurodegenerativedisease