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Biological and Clinical Aspects of Metastatic Spinal Tumors

SIMPLE SUMMARY: Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine metastases develop in the course of about 10% of malignant neoplasms. Therefore, it is essential for contemporary medicine to understand me...

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Autores principales: Litak, Jakub, Czyżewski, Wojciech, Szymoniuk, Michał, Sakwa, Leon, Pasierb, Barbara, Litak, Joanna, Hoffman, Zofia, Kamieniak, Piotr, Roliński, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559304/
https://www.ncbi.nlm.nih.gov/pubmed/36230523
http://dx.doi.org/10.3390/cancers14194599
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author Litak, Jakub
Czyżewski, Wojciech
Szymoniuk, Michał
Sakwa, Leon
Pasierb, Barbara
Litak, Joanna
Hoffman, Zofia
Kamieniak, Piotr
Roliński, Jacek
author_facet Litak, Jakub
Czyżewski, Wojciech
Szymoniuk, Michał
Sakwa, Leon
Pasierb, Barbara
Litak, Joanna
Hoffman, Zofia
Kamieniak, Piotr
Roliński, Jacek
author_sort Litak, Jakub
collection PubMed
description SIMPLE SUMMARY: Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine metastases develop in the course of about 10% of malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes in order to find appropriate, targeted therapeutic options. Our literature review aimed to describe the up-to-date knowledge about the molecular pathways and biomarkers engaged in the spine’s metastatic processes. Moreover, we described current data regarding bone-targeted treatment, the emerging targeted therapies, radiotherapy, and immunotherapy used for the treatment of spine metastases. We hope that knowledge comprehensively presented in our review will contribute to the development of novel drugs targeting specific biomarkers and pathways. The more we learn about the molecular aspects of cancer metastasis, the easier it will be to look for treatment methods that will allow us to precisely kill tumor cells. ABSTRACT: Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine metastases develop in the course of about 10% of malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes in order to find appropriate, targeted therapeutic options. Thanks to continuous research, there appears more and more detailed knowledge about cancer and metastasis, but these transformations are extremely complicated, e.g., due to the complexity of reactions, the variety of places where they occur, or the participation of both tumor cells and host cells in these transitions. The right target points in tumor metastasis mechanisms are still being researched; that will help us in the proper diagnosis as well as in finding the right treatment. In this literature review, we described the current knowledge about the molecular pathways and biomarkers engaged in metastatic processes involving the spine. We also presented a current bone-targeted treatment for spine metastases and the emerging therapies targeting the discussed molecular mechanisms.
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spelling pubmed-95593042022-10-14 Biological and Clinical Aspects of Metastatic Spinal Tumors Litak, Jakub Czyżewski, Wojciech Szymoniuk, Michał Sakwa, Leon Pasierb, Barbara Litak, Joanna Hoffman, Zofia Kamieniak, Piotr Roliński, Jacek Cancers (Basel) Review SIMPLE SUMMARY: Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine metastases develop in the course of about 10% of malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes in order to find appropriate, targeted therapeutic options. Our literature review aimed to describe the up-to-date knowledge about the molecular pathways and biomarkers engaged in the spine’s metastatic processes. Moreover, we described current data regarding bone-targeted treatment, the emerging targeted therapies, radiotherapy, and immunotherapy used for the treatment of spine metastases. We hope that knowledge comprehensively presented in our review will contribute to the development of novel drugs targeting specific biomarkers and pathways. The more we learn about the molecular aspects of cancer metastasis, the easier it will be to look for treatment methods that will allow us to precisely kill tumor cells. ABSTRACT: Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine metastases develop in the course of about 10% of malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes in order to find appropriate, targeted therapeutic options. Thanks to continuous research, there appears more and more detailed knowledge about cancer and metastasis, but these transformations are extremely complicated, e.g., due to the complexity of reactions, the variety of places where they occur, or the participation of both tumor cells and host cells in these transitions. The right target points in tumor metastasis mechanisms are still being researched; that will help us in the proper diagnosis as well as in finding the right treatment. In this literature review, we described the current knowledge about the molecular pathways and biomarkers engaged in metastatic processes involving the spine. We also presented a current bone-targeted treatment for spine metastases and the emerging therapies targeting the discussed molecular mechanisms. MDPI 2022-09-22 /pmc/articles/PMC9559304/ /pubmed/36230523 http://dx.doi.org/10.3390/cancers14194599 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Litak, Jakub
Czyżewski, Wojciech
Szymoniuk, Michał
Sakwa, Leon
Pasierb, Barbara
Litak, Joanna
Hoffman, Zofia
Kamieniak, Piotr
Roliński, Jacek
Biological and Clinical Aspects of Metastatic Spinal Tumors
title Biological and Clinical Aspects of Metastatic Spinal Tumors
title_full Biological and Clinical Aspects of Metastatic Spinal Tumors
title_fullStr Biological and Clinical Aspects of Metastatic Spinal Tumors
title_full_unstemmed Biological and Clinical Aspects of Metastatic Spinal Tumors
title_short Biological and Clinical Aspects of Metastatic Spinal Tumors
title_sort biological and clinical aspects of metastatic spinal tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559304/
https://www.ncbi.nlm.nih.gov/pubmed/36230523
http://dx.doi.org/10.3390/cancers14194599
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