RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism

Angioimmunoblastic T-cell lymphoma (AITL) is a malignant hematologic tumor arising from T follicular helper (Tfh) cells. High-throughput genomic sequencing studies have shown that AITL is characterized by a novel highly recurring somatic mutation in RHOA, encoding p.Gly17Val (RHOA G17V). However, th...

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Detalles Bibliográficos
Autores principales: Que, Fenglian, Zhang, Lihong, Wang, Taoli, Xu, Meifang, Li, Wangen, Zang, Shengbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559328/
https://www.ncbi.nlm.nih.gov/pubmed/36249275
http://dx.doi.org/10.1080/2162402X.2022.2134536

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