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Lesions causing central sleep apnea localize to one common brain network

OBJECTIVES: To characterize the specific brain regions for central sleep apnea (CSA) and identify its functional connectivity network. METHODS: We performed a literature search and identified 27 brain injuries causing CSA. We used a recently validated methodology termed “lesion network mapping” to i...

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Detalles Bibliográficos
Autores principales: Yuan, Taoyang, Zuo, Zhentao, Xu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559371/
https://www.ncbi.nlm.nih.gov/pubmed/36249869
http://dx.doi.org/10.3389/fnana.2022.819412
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author Yuan, Taoyang
Zuo, Zhentao
Xu, Jianguo
author_facet Yuan, Taoyang
Zuo, Zhentao
Xu, Jianguo
author_sort Yuan, Taoyang
collection PubMed
description OBJECTIVES: To characterize the specific brain regions for central sleep apnea (CSA) and identify its functional connectivity network. METHODS: We performed a literature search and identified 27 brain injuries causing CSA. We used a recently validated methodology termed “lesion network mapping” to identify the functional brain network subtending the pathophysiology of CSA. Two separate statistical approaches, the two-sample t-test and the Liebermeister test, were used to evaluate the specificity of this network for CSA through a comparison of our results with those of two other neurological syndromes. An additional independent cohort of six CSA cases was used to assess reproducibility. RESULTS: Our results showed that, despite lesions causing CSA being heterogeneous for brain localization, they share a common brain network defined by connectivity to the middle cingulate gyrus and bilateral cerebellar posterior lobes. This CSA-associated connectivity pattern was unique when compared with lesions causing the other two neurological syndromes. The CAS-specific regions were replicated by the additional independent cohort of six CSA cases. Finally, we found that all lesions causing CSA aligned well with the network defined by connectivity to the cingulate gyrus and bilateral cerebellar posterior lobes. CONCLUSION: Our results suggest that brain injuries responsible for CSA are part of a common brain network defined by connectivity to the middle cingulate gyrus and bilateral cerebellar posterior lobes, lending insight into the neuroanatomical substrate of CSA.
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spelling pubmed-95593712022-10-14 Lesions causing central sleep apnea localize to one common brain network Yuan, Taoyang Zuo, Zhentao Xu, Jianguo Front Neuroanat Neuroscience OBJECTIVES: To characterize the specific brain regions for central sleep apnea (CSA) and identify its functional connectivity network. METHODS: We performed a literature search and identified 27 brain injuries causing CSA. We used a recently validated methodology termed “lesion network mapping” to identify the functional brain network subtending the pathophysiology of CSA. Two separate statistical approaches, the two-sample t-test and the Liebermeister test, were used to evaluate the specificity of this network for CSA through a comparison of our results with those of two other neurological syndromes. An additional independent cohort of six CSA cases was used to assess reproducibility. RESULTS: Our results showed that, despite lesions causing CSA being heterogeneous for brain localization, they share a common brain network defined by connectivity to the middle cingulate gyrus and bilateral cerebellar posterior lobes. This CSA-associated connectivity pattern was unique when compared with lesions causing the other two neurological syndromes. The CAS-specific regions were replicated by the additional independent cohort of six CSA cases. Finally, we found that all lesions causing CSA aligned well with the network defined by connectivity to the cingulate gyrus and bilateral cerebellar posterior lobes. CONCLUSION: Our results suggest that brain injuries responsible for CSA are part of a common brain network defined by connectivity to the middle cingulate gyrus and bilateral cerebellar posterior lobes, lending insight into the neuroanatomical substrate of CSA. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9559371/ /pubmed/36249869 http://dx.doi.org/10.3389/fnana.2022.819412 Text en Copyright © 2022 Yuan, Zuo and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yuan, Taoyang
Zuo, Zhentao
Xu, Jianguo
Lesions causing central sleep apnea localize to one common brain network
title Lesions causing central sleep apnea localize to one common brain network
title_full Lesions causing central sleep apnea localize to one common brain network
title_fullStr Lesions causing central sleep apnea localize to one common brain network
title_full_unstemmed Lesions causing central sleep apnea localize to one common brain network
title_short Lesions causing central sleep apnea localize to one common brain network
title_sort lesions causing central sleep apnea localize to one common brain network
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559371/
https://www.ncbi.nlm.nih.gov/pubmed/36249869
http://dx.doi.org/10.3389/fnana.2022.819412
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