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Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis
BACKGROUND: Spontaneously ruptured hepatocellular carcinoma (rHCC) with hemorrhage is characterized by rapid onset and progression. The aim of this systematic review was to explore the current studies on rHCC with hemorrhage and determine the optimum treatment strategy. METHOD: The PubMed, Web of Sc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559597/ https://www.ncbi.nlm.nih.gov/pubmed/36249055 http://dx.doi.org/10.3389/fonc.2022.973857 |
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author | Wang, Chunling Huang, Xiaozhun Lan, Xiaofeng Lan, Dongmei Huang, Zhangkan Ye, Shu Ran, Yihong Bi, Xinyu Zhou, Jianguo Che, Xu |
author_facet | Wang, Chunling Huang, Xiaozhun Lan, Xiaofeng Lan, Dongmei Huang, Zhangkan Ye, Shu Ran, Yihong Bi, Xinyu Zhou, Jianguo Che, Xu |
author_sort | Wang, Chunling |
collection | PubMed |
description | BACKGROUND: Spontaneously ruptured hepatocellular carcinoma (rHCC) with hemorrhage is characterized by rapid onset and progression. The aim of this systematic review was to explore the current studies on rHCC with hemorrhage and determine the optimum treatment strategy. METHOD: The PubMed, Web of Science, Embase, and the Cochrane Library databases were searched for studies reporting survival outcomes with comparison between emergency resection (ER) and transarterial embolization following staged hepatectomy (SH) were included by inclusion and exclusion criteria, the perioperative and survival data were statistically summarized using Review Manager 5.3 software. RESULT: A total of 8 retrospective studies were included, with a total sample size of 556, including 285 (51.3%) in the ER group and 271 (48.7%) in the SH group. The perioperative blood loss and blood transfusion volume in the SH group were less than those in the ER group, and there were no significant differences in the operative time, incidence of complications, mortality and recurrence rate of tumors between the two groups. The 1-, 2-, 3-year overall survival and 1-, 2-, 3-, 5-year disease-free survival of the ER group were not significantly different from those of the SH group, and the 5-year overall survival rate of ER group was lower than that of the SH group (hazard ratios=1.52; 95% confidence intervals: 1.14-2.03, P=0.005). CONCLUSION: There was no significant difference in the short-term efficacy of ER or SH in the treatment of ruptured HCC, and SH was superior to ER in the long-term survival. |
format | Online Article Text |
id | pubmed-9559597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95595972022-10-14 Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis Wang, Chunling Huang, Xiaozhun Lan, Xiaofeng Lan, Dongmei Huang, Zhangkan Ye, Shu Ran, Yihong Bi, Xinyu Zhou, Jianguo Che, Xu Front Oncol Oncology BACKGROUND: Spontaneously ruptured hepatocellular carcinoma (rHCC) with hemorrhage is characterized by rapid onset and progression. The aim of this systematic review was to explore the current studies on rHCC with hemorrhage and determine the optimum treatment strategy. METHOD: The PubMed, Web of Science, Embase, and the Cochrane Library databases were searched for studies reporting survival outcomes with comparison between emergency resection (ER) and transarterial embolization following staged hepatectomy (SH) were included by inclusion and exclusion criteria, the perioperative and survival data were statistically summarized using Review Manager 5.3 software. RESULT: A total of 8 retrospective studies were included, with a total sample size of 556, including 285 (51.3%) in the ER group and 271 (48.7%) in the SH group. The perioperative blood loss and blood transfusion volume in the SH group were less than those in the ER group, and there were no significant differences in the operative time, incidence of complications, mortality and recurrence rate of tumors between the two groups. The 1-, 2-, 3-year overall survival and 1-, 2-, 3-, 5-year disease-free survival of the ER group were not significantly different from those of the SH group, and the 5-year overall survival rate of ER group was lower than that of the SH group (hazard ratios=1.52; 95% confidence intervals: 1.14-2.03, P=0.005). CONCLUSION: There was no significant difference in the short-term efficacy of ER or SH in the treatment of ruptured HCC, and SH was superior to ER in the long-term survival. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9559597/ /pubmed/36249055 http://dx.doi.org/10.3389/fonc.2022.973857 Text en Copyright © 2022 Wang, Huang, Lan, Lan, Huang, Ye, Ran, Bi, Zhou and Che https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wang, Chunling Huang, Xiaozhun Lan, Xiaofeng Lan, Dongmei Huang, Zhangkan Ye, Shu Ran, Yihong Bi, Xinyu Zhou, Jianguo Che, Xu Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis |
title | Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis |
title_full | Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis |
title_fullStr | Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis |
title_full_unstemmed | Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis |
title_short | Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis |
title_sort | research progress of spontaneous ruptured hepatocellular carcinoma: systematic review and meta-analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559597/ https://www.ncbi.nlm.nih.gov/pubmed/36249055 http://dx.doi.org/10.3389/fonc.2022.973857 |
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