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Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene are associated with increased risk for late-onset AD. Genetic loss of or decreased TREM2 function impairs the microglial response to amyloid-β (Aβ) plaques, resulting in more diffuse Aβ plaques and increased peri-plaque ne...

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Detalles Bibliográficos
Autores principales:	Jain, Nimansha, Lewis, Caroline A., Ulrich, Jason D., Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559604/ https://www.ncbi.nlm.nih.gov/pubmed/36219197 http://dx.doi.org/10.1084/jem.20220654

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