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Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy

Duchenne muscular dystrophy, like other muscular dystrophies, is a progressive disorder hallmarked by muscle degeneration, inflammation, and fibrosis. Latent transforming growth factor β (TGFβ) binding protein 4 (LTBP4) is an extracellular matrix protein found in muscle. LTBP4 sequesters and inhibit...

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Detalles Bibliográficos
Autores principales:	Demonbreun, Alexis R., Fallon, Katherine S., Oosterbaan, Claire C., Vaught, Lauren A., Reiser, Nina L., Bogdanovic, Elena, Velez, Matthew P., Salamone, Isabella M., Page, Patrick G.T., Hadhazy, Michele, Quattrocelli, Mattia, Barefield, David Y., Wood, Lauren D., Gonzalez, J. Patrick, Morris, Carl, McNally, Elizabeth M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559620/ https://www.ncbi.nlm.nih.gov/pubmed/34516828 http://dx.doi.org/10.1126/scitranslmed.abf0376

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