Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

BACKGROUND: Poguntano (Picria fel-terrae Merr) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established. OBJECTIVE: This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels. METHODS: We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model. RESULTS: Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20–51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract. CONCLUSION: Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.