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Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity

In the bispotted field cricket auditory pulse pattern recognition of the species-specific calling song is based on a delay-line and coincidence detection network, established by the activity and synaptic connections of only 5 auditory neurons in the brain. To obtain a more detailed understanding of...

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Autores principales: Zhang, Xinyang, Hedwig, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559836/
https://www.ncbi.nlm.nih.gov/pubmed/36246524
http://dx.doi.org/10.3389/fncel.2022.1010740
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author Zhang, Xinyang
Hedwig, Berthold
author_facet Zhang, Xinyang
Hedwig, Berthold
author_sort Zhang, Xinyang
collection PubMed
description In the bispotted field cricket auditory pulse pattern recognition of the species-specific calling song is based on a delay-line and coincidence detection network, established by the activity and synaptic connections of only 5 auditory neurons in the brain. To obtain a more detailed understanding of the network and the dynamic of the neural activity over time we analyzed the response properties of these neurons to test patterns, in which the pulse duration was kept constant while the duration of specific pulse intervals was systematically altered. We confirm that the ascending interneuron AN1 and the local interneuron LN2 copy the structure of the pulse pattern, however with limited resolution at short pulse intervals, further evident in downstream neural responses. In the non-spiking delay-line interneuron LN5 during long pulse intervals full-blown rebound potentials develop over a time course of 35–70 ms. LN5 also reveals an overall increase in its membrane potential tuned to chirps of the calling song pulse pattern. This may contribute to the pattern recognition process by driving the activity of the coincidence-detector LN3 and may indicate a further function of the delay-line neuron LN5. The activity of LN3 and of the feature detector LN4 match the tuning of the phonotactic behavior and demonstrate an increasingly sparse coding of the calling song pulse patterns as evident in the response of the feature detector LN4. The circuitry reveals a fundamental mechanism of auditory pattern recognition and demonstrates a principle of neuronal coding.
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spelling pubmed-95598362022-10-14 Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity Zhang, Xinyang Hedwig, Berthold Front Cell Neurosci Cellular Neuroscience In the bispotted field cricket auditory pulse pattern recognition of the species-specific calling song is based on a delay-line and coincidence detection network, established by the activity and synaptic connections of only 5 auditory neurons in the brain. To obtain a more detailed understanding of the network and the dynamic of the neural activity over time we analyzed the response properties of these neurons to test patterns, in which the pulse duration was kept constant while the duration of specific pulse intervals was systematically altered. We confirm that the ascending interneuron AN1 and the local interneuron LN2 copy the structure of the pulse pattern, however with limited resolution at short pulse intervals, further evident in downstream neural responses. In the non-spiking delay-line interneuron LN5 during long pulse intervals full-blown rebound potentials develop over a time course of 35–70 ms. LN5 also reveals an overall increase in its membrane potential tuned to chirps of the calling song pulse pattern. This may contribute to the pattern recognition process by driving the activity of the coincidence-detector LN3 and may indicate a further function of the delay-line neuron LN5. The activity of LN3 and of the feature detector LN4 match the tuning of the phonotactic behavior and demonstrate an increasingly sparse coding of the calling song pulse patterns as evident in the response of the feature detector LN4. The circuitry reveals a fundamental mechanism of auditory pattern recognition and demonstrates a principle of neuronal coding. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9559836/ /pubmed/36246524 http://dx.doi.org/10.3389/fncel.2022.1010740 Text en Copyright © 2022 Zhang and Hedwig. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Zhang, Xinyang
Hedwig, Berthold
Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
title Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
title_full Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
title_fullStr Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
title_full_unstemmed Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
title_short Response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
title_sort response properties of spiking and non-spiking brain neurons mirror pulse interval selectivity
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559836/
https://www.ncbi.nlm.nih.gov/pubmed/36246524
http://dx.doi.org/10.3389/fncel.2022.1010740
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