Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions

BACKGROUND: Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of these receptors are lacking. The development of new P2X7-speci...

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Detalles Bibliográficos
Autores principales: Wilmes, Maximilian, Pinto Espinoza, Carolina, Ludewig, Peter, Stabernack, Joschi, Liesz, Arthur, Nicke, Annette, Gelderblom, Mathias, Gerloff, Christian, Falzoni, Simonetta, Tolosa, Eva, Di Virgilio, Francesco, Rissiek, Björn, Plesnilla, Nikolaus, Koch-Nolte, Friedrich, Magnus, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559872/
https://www.ncbi.nlm.nih.gov/pubmed/36224611
http://dx.doi.org/10.1186/s12974-022-02601-z

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