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An Optimized Treatment Protocol for Subretinal Injections Limits Intravitreal Vector Distribution

PURPOSE: Subretinal injections (SRis) are commonly used in retinal gene therapy procedures to deliver adeno-associated virus (AAV) to photoreceptors and retinal pigment epithelial cells. We present an optimized surgical protocol to minimize off-target application of AAV in the vitreous, which in tur...

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Detalles Bibliográficos
Autores principales:	Reichel, Felix F.L., Wozar, Fabian, Seitz, Immanuel, Ochakovski, Alex, Bartz-Schmidt, K. Ulrich, Peters, Tobias, Fischer, M. Dominik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559903/ https://www.ncbi.nlm.nih.gov/pubmed/36247814 http://dx.doi.org/10.1016/j.xops.2021.100050

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