Cargando…
Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression
The tumor suppressor p53 regulates various stress responses via increasing its cellular levels. The lowest p53 levels occur in unstressed cells; however, the functions of these low levels remain unclear. To investigate the functions, we used empirical single-cell tracking of p53-expressing (Control)...
Autores principales: | Rancourt, Ann, Sato, Sachiko, Satoh, Masahiko S |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560164/ https://www.ncbi.nlm.nih.gov/pubmed/36125118 http://dx.doi.org/10.7554/eLife.72498 |
Ejemplares similares
-
Single-cell lineage tracking analysis reveals that an established cell line comprises putative cancer stem cells and their heterogeneous progeny
por: Sato, Sachiko, et al.
Publicado: (2016) -
Bias in nutrition-health associations is not eliminated by excluding extreme reporters in empirical or simulation studies
por: Yamamoto, Nao, et al.
Publicado: (2023) -
Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation
por: Peláez, Nicolás, et al.
Publicado: (2015) -
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination
por: Choi, Jinmi, et al.
Publicado: (2021) -
Dose-dependent spatiotemporal responses of mammalian cells to an alkylating agent
por: Rancourt, Ann, et al.
Publicado: (2019)