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The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern

COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune...

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Autores principales: Graham, Carl, Lechmere, Thomas, Rehman, Aisha, Seow, Jeffrey, Kurshan, Ashwini, Huettner, Isabella, Maguire, Thomas J. A., Tam, Jerry C. H., Cox, Daniel, Ward, Christopher, Racz, Mariusz, Waters, Anele, Mant, Christine, Malim, Michael H., Fox, Julie, Doores, Katie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560610/
https://www.ncbi.nlm.nih.gov/pubmed/36191037
http://dx.doi.org/10.1371/journal.ppat.1010882
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author Graham, Carl
Lechmere, Thomas
Rehman, Aisha
Seow, Jeffrey
Kurshan, Ashwini
Huettner, Isabella
Maguire, Thomas J. A.
Tam, Jerry C. H.
Cox, Daniel
Ward, Christopher
Racz, Mariusz
Waters, Anele
Mant, Christine
Malim, Michael H.
Fox, Julie
Doores, Katie J.
author_facet Graham, Carl
Lechmere, Thomas
Rehman, Aisha
Seow, Jeffrey
Kurshan, Ashwini
Huettner, Isabella
Maguire, Thomas J. A.
Tam, Jerry C. H.
Cox, Daniel
Ward, Christopher
Racz, Mariusz
Waters, Anele
Mant, Christine
Malim, Michael H.
Fox, Julie
Doores, Katie J.
author_sort Graham, Carl
collection PubMed
description COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune responses. We compared the magnitude and breadth of the neutralizing antibody response, as well as levels of Spike-reactive memory B cells, in individuals receiving a second dose of BNT162b2 at a short (3–4 week) or extended interval (8–12 weeks) and following a third vaccination approximately 6–8 months later. We show that whilst an extended interval between the first two vaccinations can greatly increase the breadth of the immune response and generate a higher proportion of Spike reactive memory B cells, a third vaccination leads to similar levels between the two groups. Furthermore, we show that the third vaccine dose enhances neutralization activity against omicron lineage members BA.1, BA.2 and BA.4/BA.5 and this is further increased following breakthrough infection during the UK omicron wave. These findings are relevant for vaccination strategies in populations where COVID-19 vaccine coverage remains low.
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spelling pubmed-95606102022-10-14 The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern Graham, Carl Lechmere, Thomas Rehman, Aisha Seow, Jeffrey Kurshan, Ashwini Huettner, Isabella Maguire, Thomas J. A. Tam, Jerry C. H. Cox, Daniel Ward, Christopher Racz, Mariusz Waters, Anele Mant, Christine Malim, Michael H. Fox, Julie Doores, Katie J. PLoS Pathog Research Article COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune responses. We compared the magnitude and breadth of the neutralizing antibody response, as well as levels of Spike-reactive memory B cells, in individuals receiving a second dose of BNT162b2 at a short (3–4 week) or extended interval (8–12 weeks) and following a third vaccination approximately 6–8 months later. We show that whilst an extended interval between the first two vaccinations can greatly increase the breadth of the immune response and generate a higher proportion of Spike reactive memory B cells, a third vaccination leads to similar levels between the two groups. Furthermore, we show that the third vaccine dose enhances neutralization activity against omicron lineage members BA.1, BA.2 and BA.4/BA.5 and this is further increased following breakthrough infection during the UK omicron wave. These findings are relevant for vaccination strategies in populations where COVID-19 vaccine coverage remains low. Public Library of Science 2022-10-03 /pmc/articles/PMC9560610/ /pubmed/36191037 http://dx.doi.org/10.1371/journal.ppat.1010882 Text en © 2022 Graham et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Graham, Carl
Lechmere, Thomas
Rehman, Aisha
Seow, Jeffrey
Kurshan, Ashwini
Huettner, Isabella
Maguire, Thomas J. A.
Tam, Jerry C. H.
Cox, Daniel
Ward, Christopher
Racz, Mariusz
Waters, Anele
Mant, Christine
Malim, Michael H.
Fox, Julie
Doores, Katie J.
The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
title The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
title_full The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
title_fullStr The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
title_full_unstemmed The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
title_short The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
title_sort effect of omicron breakthrough infection and extended bnt162b2 booster dosing on neutralization breadth against sars-cov-2 variants of concern
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560610/
https://www.ncbi.nlm.nih.gov/pubmed/36191037
http://dx.doi.org/10.1371/journal.ppat.1010882
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