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The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560610/ https://www.ncbi.nlm.nih.gov/pubmed/36191037 http://dx.doi.org/10.1371/journal.ppat.1010882 |
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author | Graham, Carl Lechmere, Thomas Rehman, Aisha Seow, Jeffrey Kurshan, Ashwini Huettner, Isabella Maguire, Thomas J. A. Tam, Jerry C. H. Cox, Daniel Ward, Christopher Racz, Mariusz Waters, Anele Mant, Christine Malim, Michael H. Fox, Julie Doores, Katie J. |
author_facet | Graham, Carl Lechmere, Thomas Rehman, Aisha Seow, Jeffrey Kurshan, Ashwini Huettner, Isabella Maguire, Thomas J. A. Tam, Jerry C. H. Cox, Daniel Ward, Christopher Racz, Mariusz Waters, Anele Mant, Christine Malim, Michael H. Fox, Julie Doores, Katie J. |
author_sort | Graham, Carl |
collection | PubMed |
description | COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune responses. We compared the magnitude and breadth of the neutralizing antibody response, as well as levels of Spike-reactive memory B cells, in individuals receiving a second dose of BNT162b2 at a short (3–4 week) or extended interval (8–12 weeks) and following a third vaccination approximately 6–8 months later. We show that whilst an extended interval between the first two vaccinations can greatly increase the breadth of the immune response and generate a higher proportion of Spike reactive memory B cells, a third vaccination leads to similar levels between the two groups. Furthermore, we show that the third vaccine dose enhances neutralization activity against omicron lineage members BA.1, BA.2 and BA.4/BA.5 and this is further increased following breakthrough infection during the UK omicron wave. These findings are relevant for vaccination strategies in populations where COVID-19 vaccine coverage remains low. |
format | Online Article Text |
id | pubmed-9560610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95606102022-10-14 The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern Graham, Carl Lechmere, Thomas Rehman, Aisha Seow, Jeffrey Kurshan, Ashwini Huettner, Isabella Maguire, Thomas J. A. Tam, Jerry C. H. Cox, Daniel Ward, Christopher Racz, Mariusz Waters, Anele Mant, Christine Malim, Michael H. Fox, Julie Doores, Katie J. PLoS Pathog Research Article COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune responses. We compared the magnitude and breadth of the neutralizing antibody response, as well as levels of Spike-reactive memory B cells, in individuals receiving a second dose of BNT162b2 at a short (3–4 week) or extended interval (8–12 weeks) and following a third vaccination approximately 6–8 months later. We show that whilst an extended interval between the first two vaccinations can greatly increase the breadth of the immune response and generate a higher proportion of Spike reactive memory B cells, a third vaccination leads to similar levels between the two groups. Furthermore, we show that the third vaccine dose enhances neutralization activity against omicron lineage members BA.1, BA.2 and BA.4/BA.5 and this is further increased following breakthrough infection during the UK omicron wave. These findings are relevant for vaccination strategies in populations where COVID-19 vaccine coverage remains low. Public Library of Science 2022-10-03 /pmc/articles/PMC9560610/ /pubmed/36191037 http://dx.doi.org/10.1371/journal.ppat.1010882 Text en © 2022 Graham et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Graham, Carl Lechmere, Thomas Rehman, Aisha Seow, Jeffrey Kurshan, Ashwini Huettner, Isabella Maguire, Thomas J. A. Tam, Jerry C. H. Cox, Daniel Ward, Christopher Racz, Mariusz Waters, Anele Mant, Christine Malim, Michael H. Fox, Julie Doores, Katie J. The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern |
title | The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern |
title_full | The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern |
title_fullStr | The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern |
title_full_unstemmed | The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern |
title_short | The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern |
title_sort | effect of omicron breakthrough infection and extended bnt162b2 booster dosing on neutralization breadth against sars-cov-2 variants of concern |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560610/ https://www.ncbi.nlm.nih.gov/pubmed/36191037 http://dx.doi.org/10.1371/journal.ppat.1010882 |
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