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Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis

INTRODUCTION: Traumatic brain injury (TBI) rates in the elderly are increasing worldwide, mainly due to fall accidents. However, TBI's impact on elderly patients' lives has not been thoroughly investigated. RESEARCH QUESTION: This systematic review and meta-analysis aims at describing post...

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Autores principales: Gavrila Laic, Rebeca Alejandra, Bogaert, Liedewij, Vander Sloten, Jos, Depreitere, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560680/
https://www.ncbi.nlm.nih.gov/pubmed/36247393
http://dx.doi.org/10.1016/j.bas.2021.100849
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author Gavrila Laic, Rebeca Alejandra
Bogaert, Liedewij
Vander Sloten, Jos
Depreitere, Bart
author_facet Gavrila Laic, Rebeca Alejandra
Bogaert, Liedewij
Vander Sloten, Jos
Depreitere, Bart
author_sort Gavrila Laic, Rebeca Alejandra
collection PubMed
description INTRODUCTION: Traumatic brain injury (TBI) rates in the elderly are increasing worldwide, mainly due to fall accidents. However, TBI's impact on elderly patients' lives has not been thoroughly investigated. RESEARCH QUESTION: This systematic review and meta-analysis aims at describing post-TBI incidence of functional decline, dependency, nursing home admission, reduced quality of life and depression in the elderly. MATERIALS AND METHODS: A systematic literature search was performed in PubMed, EMBASE, Web Of Science, BIOSIS, Current Contents Connect, Data Citation Index, MEDLINE, SciELO, Cochrane library and CINAHL. Study selection was conducted by two independent reviewers. Meta-analysis was performed using a random-effects model. RESULTS: Twenty-seven studies were included in the qualitative synthesis and twenty-five in a random-effects meta-analysis. The prevalence of unfavorable functional outcomes after TBI was 65.2% (95% CI: 51.1–78.0). Admission to a nursing home had a pooled prevalence of 28.5% (95% CI: 17.1–41.6) and dependency rates ranged between 16.9% and 74.0%. A reduced quality of life was documented throughout follow-up with SF12/36 scores between 35.3 and 52.3/100.2.6–4.8% of the patients with mild TBI reported depressive symptoms. A large heterogeneity was found among studies for functional outcomes and discharge destination. DISCUSSION AND CONCLUSION: In conclusion, elderly patients have a significant risk for functional decline, dependency, nursing home admission and low quality of life following TBI. Moreover, more severe injuries lead to worse outcomes. These findings are important to provide accurate patient and family counseling, set realistic treatment targets and aim at relevant outcome variables in prognostic models for TBI in elderly patients.
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spelling pubmed-95606802022-10-14 Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis Gavrila Laic, Rebeca Alejandra Bogaert, Liedewij Vander Sloten, Jos Depreitere, Bart Brain Spine Review INTRODUCTION: Traumatic brain injury (TBI) rates in the elderly are increasing worldwide, mainly due to fall accidents. However, TBI's impact on elderly patients' lives has not been thoroughly investigated. RESEARCH QUESTION: This systematic review and meta-analysis aims at describing post-TBI incidence of functional decline, dependency, nursing home admission, reduced quality of life and depression in the elderly. MATERIALS AND METHODS: A systematic literature search was performed in PubMed, EMBASE, Web Of Science, BIOSIS, Current Contents Connect, Data Citation Index, MEDLINE, SciELO, Cochrane library and CINAHL. Study selection was conducted by two independent reviewers. Meta-analysis was performed using a random-effects model. RESULTS: Twenty-seven studies were included in the qualitative synthesis and twenty-five in a random-effects meta-analysis. The prevalence of unfavorable functional outcomes after TBI was 65.2% (95% CI: 51.1–78.0). Admission to a nursing home had a pooled prevalence of 28.5% (95% CI: 17.1–41.6) and dependency rates ranged between 16.9% and 74.0%. A reduced quality of life was documented throughout follow-up with SF12/36 scores between 35.3 and 52.3/100.2.6–4.8% of the patients with mild TBI reported depressive symptoms. A large heterogeneity was found among studies for functional outcomes and discharge destination. DISCUSSION AND CONCLUSION: In conclusion, elderly patients have a significant risk for functional decline, dependency, nursing home admission and low quality of life following TBI. Moreover, more severe injuries lead to worse outcomes. These findings are important to provide accurate patient and family counseling, set realistic treatment targets and aim at relevant outcome variables in prognostic models for TBI in elderly patients. Elsevier 2021-12-02 /pmc/articles/PMC9560680/ /pubmed/36247393 http://dx.doi.org/10.1016/j.bas.2021.100849 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Gavrila Laic, Rebeca Alejandra
Bogaert, Liedewij
Vander Sloten, Jos
Depreitere, Bart
Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis
title Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis
title_full Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis
title_fullStr Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis
title_full_unstemmed Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis
title_short Functional outcome, dependency and well-being after traumatic brain injury in the elderly population: A systematic review and meta-analysis
title_sort functional outcome, dependency and well-being after traumatic brain injury in the elderly population: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560680/
https://www.ncbi.nlm.nih.gov/pubmed/36247393
http://dx.doi.org/10.1016/j.bas.2021.100849
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