Cargando…

Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media

The dynamics of blood flow in the smallest vessels and passages of the human body, where the cellular character of blood becomes prominent, plays a dominant role in the transport and exchange of solutes. Recent studies have revealed that the microhaemodynamics of a vascular network is underpinned by...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Qi, Schirrmann, Kerstin, Doman, Eleanor, Chen, Qi, Singh, Naval, Selvaganapathy, P. Ravi, Bernabeu, Miguel O., Jensen, Oliver E., Juel, Anne, Chernyavsky, Igor L., Krüger, Timm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560785/
https://www.ncbi.nlm.nih.gov/pubmed/36325194
http://dx.doi.org/10.1098/rsfs.2022.0037
_version_ 1784807831041474560
author Zhou, Qi
Schirrmann, Kerstin
Doman, Eleanor
Chen, Qi
Singh, Naval
Selvaganapathy, P. Ravi
Bernabeu, Miguel O.
Jensen, Oliver E.
Juel, Anne
Chernyavsky, Igor L.
Krüger, Timm
author_facet Zhou, Qi
Schirrmann, Kerstin
Doman, Eleanor
Chen, Qi
Singh, Naval
Selvaganapathy, P. Ravi
Bernabeu, Miguel O.
Jensen, Oliver E.
Juel, Anne
Chernyavsky, Igor L.
Krüger, Timm
author_sort Zhou, Qi
collection PubMed
description The dynamics of blood flow in the smallest vessels and passages of the human body, where the cellular character of blood becomes prominent, plays a dominant role in the transport and exchange of solutes. Recent studies have revealed that the microhaemodynamics of a vascular network is underpinned by its interconnected structure, and certain structural alterations such as capillary dilation and blockage can substantially change blood flow patterns. However, for extravascular media with disordered microstructure (e.g. the porous intervillous space in the placenta), it remains unclear how the medium’s structure affects the haemodynamics. Here, we simulate cellular blood flow in simple models of canonical porous media representative of extravascular biological tissue, with corroborative microfluidic experiments performed for validation purposes. For the media considered here, we observe three main effects: first, the relative apparent viscosity of blood increases with the structural disorder of the medium; second, the presence of red blood cells (RBCs) dynamically alters the flow distribution in the medium; third, symmetry breaking introduced by moderate structural disorder can promote more homogeneous distribution of RBCs. Our findings contribute to a better understanding of the cell-scale haemodynamics that mediates the relationship linking the function of certain biological tissues to their microstructure.
format Online
Article
Text
id pubmed-9560785
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-95607852022-11-01 Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media Zhou, Qi Schirrmann, Kerstin Doman, Eleanor Chen, Qi Singh, Naval Selvaganapathy, P. Ravi Bernabeu, Miguel O. Jensen, Oliver E. Juel, Anne Chernyavsky, Igor L. Krüger, Timm Interface Focus Articles The dynamics of blood flow in the smallest vessels and passages of the human body, where the cellular character of blood becomes prominent, plays a dominant role in the transport and exchange of solutes. Recent studies have revealed that the microhaemodynamics of a vascular network is underpinned by its interconnected structure, and certain structural alterations such as capillary dilation and blockage can substantially change blood flow patterns. However, for extravascular media with disordered microstructure (e.g. the porous intervillous space in the placenta), it remains unclear how the medium’s structure affects the haemodynamics. Here, we simulate cellular blood flow in simple models of canonical porous media representative of extravascular biological tissue, with corroborative microfluidic experiments performed for validation purposes. For the media considered here, we observe three main effects: first, the relative apparent viscosity of blood increases with the structural disorder of the medium; second, the presence of red blood cells (RBCs) dynamically alters the flow distribution in the medium; third, symmetry breaking introduced by moderate structural disorder can promote more homogeneous distribution of RBCs. Our findings contribute to a better understanding of the cell-scale haemodynamics that mediates the relationship linking the function of certain biological tissues to their microstructure. The Royal Society 2022-10-14 /pmc/articles/PMC9560785/ /pubmed/36325194 http://dx.doi.org/10.1098/rsfs.2022.0037 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Zhou, Qi
Schirrmann, Kerstin
Doman, Eleanor
Chen, Qi
Singh, Naval
Selvaganapathy, P. Ravi
Bernabeu, Miguel O.
Jensen, Oliver E.
Juel, Anne
Chernyavsky, Igor L.
Krüger, Timm
Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
title Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
title_full Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
title_fullStr Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
title_full_unstemmed Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
title_short Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
title_sort red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560785/
https://www.ncbi.nlm.nih.gov/pubmed/36325194
http://dx.doi.org/10.1098/rsfs.2022.0037
work_keys_str_mv AT zhouqi redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT schirrmannkerstin redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT domaneleanor redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT chenqi redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT singhnaval redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT selvaganapathypravi redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT bernabeumiguelo redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT jensenolivere redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT juelanne redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT chernyavskyigorl redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia
AT krugertimm redbloodcelldynamicsinextravascularbiologicaltissuesmodelledascanonicaldisorderedporousmedia