Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia

The pathological features of PDD are represented by dopaminergic neuronal death and intracellular α-synuclein (α-syn) aggregation. The interaction of iron accumulation with α-syn and tau was further explored as an essential pathological mechanism of PDD. However, the links and mechanisms between the...

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Detalles Bibliográficos
Autores principales: Li, Mengzhu, Fan, Yaohua, Li, Qinglian, Wang, Xiaoling, Zhao, Lijun, Zhu, Meiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560807/
https://www.ncbi.nlm.nih.gov/pubmed/36246407
http://dx.doi.org/10.1155/2022/7165387

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