Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research

African swine fever virus (ASFV) is a highly pathogenic double-stranded DNA virus. It affects various breeds of pigs, causing serious economic losses and health threats because of its rapid spread and high pathogenicity and infectivity. This situation is not helped by the lack of a validated vaccine...

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Autores principales: Zhang, Xiaoyue, Wang, Zhenzhong, Ge, Shengqiang, Zuo, Yuanyuan, Lu, Haodong, Lv, Yan, Han, Naijun, Cai, Yumei, Wu, Xiaodong, Wang, Zhiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560881/
https://www.ncbi.nlm.nih.gov/pubmed/36229722
http://dx.doi.org/10.1007/s11262-022-01939-z
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author Zhang, Xiaoyue
Wang, Zhenzhong
Ge, Shengqiang
Zuo, Yuanyuan
Lu, Haodong
Lv, Yan
Han, Naijun
Cai, Yumei
Wu, Xiaodong
Wang, Zhiliang
author_facet Zhang, Xiaoyue
Wang, Zhenzhong
Ge, Shengqiang
Zuo, Yuanyuan
Lu, Haodong
Lv, Yan
Han, Naijun
Cai, Yumei
Wu, Xiaodong
Wang, Zhiliang
author_sort Zhang, Xiaoyue
collection PubMed
description African swine fever virus (ASFV) is a highly pathogenic double-stranded DNA virus. It affects various breeds of pigs, causing serious economic losses and health threats because of its rapid spread and high pathogenicity and infectivity. This situation is not helped by the lack of a validated vaccine or effective therapies. Since the 1960s, different strains of ASFV have been subjected to serial passage in a variety of cell lines. The attenuated ASFV strains obtained through serial passage are not only candidates for ASF vaccine research, but also are useful to study the molecular genetic characteristics and pathogenic mechanism of the virus. This review summarizes related studies on the attenuated strains of ASFV acquired through cell passage over the last 60 years, with the aim of providing inspiration for the rational design of vaccines in future.
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spelling pubmed-95608812022-10-14 Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research Zhang, Xiaoyue Wang, Zhenzhong Ge, Shengqiang Zuo, Yuanyuan Lu, Haodong Lv, Yan Han, Naijun Cai, Yumei Wu, Xiaodong Wang, Zhiliang Virus Genes Review Paper African swine fever virus (ASFV) is a highly pathogenic double-stranded DNA virus. It affects various breeds of pigs, causing serious economic losses and health threats because of its rapid spread and high pathogenicity and infectivity. This situation is not helped by the lack of a validated vaccine or effective therapies. Since the 1960s, different strains of ASFV have been subjected to serial passage in a variety of cell lines. The attenuated ASFV strains obtained through serial passage are not only candidates for ASF vaccine research, but also are useful to study the molecular genetic characteristics and pathogenic mechanism of the virus. This review summarizes related studies on the attenuated strains of ASFV acquired through cell passage over the last 60 years, with the aim of providing inspiration for the rational design of vaccines in future. Springer US 2022-10-14 2023 /pmc/articles/PMC9560881/ /pubmed/36229722 http://dx.doi.org/10.1007/s11262-022-01939-z Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Paper
Zhang, Xiaoyue
Wang, Zhenzhong
Ge, Shengqiang
Zuo, Yuanyuan
Lu, Haodong
Lv, Yan
Han, Naijun
Cai, Yumei
Wu, Xiaodong
Wang, Zhiliang
Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
title Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
title_full Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
title_fullStr Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
title_full_unstemmed Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
title_short Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
title_sort attenuated african swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560881/
https://www.ncbi.nlm.nih.gov/pubmed/36229722
http://dx.doi.org/10.1007/s11262-022-01939-z
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