Cargando…

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway

The chiral molecule, apomorphine, is currently used for the treatment of Parkinson’s disease (PD). As a potent dopamine receptor agonist, this lipophilic compound is especially effective for treating motor fluctuations in advanced PD patients. In addition to its receptor-mediated actions, apomorphin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heurtaux, Tony, Kirchmeyer, Melanie, Koncina, Eric, Felten, Paul, Richart, Lorraine, Uriarte Huarte, Oihane, Schohn, Herve, Mittelbronn, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9560932/ https://www.ncbi.nlm.nih.gov/pubmed/34415465 http://dx.doi.org/10.1007/s10571-021-01131-1

Ejemplares similares

Microglia in Health and Disease: The Strength to Be Diverse and Reactive
por: Uriarte Huarte, Oihane, et al.
Publicado: (2021)

Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant
por: Hoenen, Claire, et al.
Publicado: (2016)

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes
por: Gustin, Audrey, et al.
Publicado: (2015)

Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
por: Uriarte Huarte, Oihane, et al.
Publicado: (2021)

Neurodegeneration and neuroinflammation are linked, but independent of alpha‐synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease
por: Garcia, Pierre, et al.
Publicado: (2022)

Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
por: Fixemer, Sonja, et al.
Publicado: (2022)

Normal and Pathological NRF2 Signalling in the Central Nervous System
por: Heurtaux, Tony, et al.
Publicado: (2022)

Apomorphine
Publicado: (1900)

Apomorphine
Publicado: (1888)

Microfluidics-free single-cell genomics reveals complex central-peripheral immune crosstalk in the mouse brain during peripheral inflammation
por: Tansey, Malú, et al.
Publicado: (2023)

Apomorphine effects on the hippocampus
por: Arroyo-García, Luis Enrique, et al.
Publicado: (2018)

On the Anæsthetic Action of Apomorphine
Publicado: (1885)

Transcriptomic analyses of primary astrocytes under TNFα treatment
por: Birck, Cindy, et al.
Publicado: (2015)

Some Observations on the Use of Apomorphine
por: Horsley, J. S.
Publicado: (1912)

Is Apomorphine a Safe Emetic?
por: Brown, John
Publicado: (1889)

Apomorphine formulation may influence subcutaneous complications from continuous subcutaneous apomorphine infusion in Parkinson’s disease
por: Hagell, Peter, et al.
Publicado: (2020)

Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease
por: Agbo, Felix, et al.
Publicado: (2021)

Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
por: Gillett, Drew A., et al.
Publicado: (2023)

Apomorphine Hydrochloride in the Treatment of Persistent Hiccough
por: Panda, R. C.
Publicado: (1928)

The Pharmacological Properties and Therapeutic Use of Apomorphine
por: Ribarič, Samo
Publicado: (2012)

Apomorphine in Parkinson's Disease—The Questions Raised
por: Dhamija, Rajinder K., et al.
Publicado: (2020)

Looking Beyond the Fog—Apomorphine Demystified
por: LK, Prashanth, et al.
Publicado: (2020)

Necrotic Ulcers Secondary to Apomorphine Infusion
por: Llamas-Osorio, Yudy, et al.
Publicado: (2021)

Loss of the Synuclein Family Members Differentially Affects Baseline- and Apomorphine-Associated EEG Determinants in Single-, Double- and Triple-Knockout Mice
por: Vorobyov, Vasily, et al.
Publicado: (2022)

Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation
por: Gabel, Sebastien, et al.
Publicado: (2015)

The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective
por: Bouvier, David S., et al.
Publicado: (2022)

A Case of Hiccough Cured with Apomorphine Hydrochloride
por: Dutt, K. N.
Publicado: (1933)

Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq
por: Turbant, Florian, et al.
Publicado: (2021)

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis()
por: Mead, Richard J., et al.
Publicado: (2013)

Effect of apomorphine on cognitive performance and sensorimotor gating in humans
por: Schellekens, Arnt F. A., et al.
Publicado: (2009)

Apomorphine and Levodopa Infusion Therapies for Advanced Parkinson’s Disease
por: Antonini, Angelo
Publicado: (2009)

Au nanoparticle-based sensor for apomorphine detection in plasma
por: Zanchi, Chiara, et al.
Publicado: (2015)

Stability of apomorphine in solutions containing selected antioxidant agents
por: Ang, Zen Yang, et al.
Publicado: (2016)

Task Specific Tremor in Parkinson’s Disease Responds to Apomorphine
por: Ondo, William G., et al.
Publicado: (2023)

Night‐Time Apomorphine Infusion: Who Are the Best Candidates?
por: Cochen De Cock, Valérie, et al.
Publicado: (2023)

Apomorphine Monotherapy for Parkinson’s Disease: A Neglected Option?
por: Desjardins, Clément, et al.
Publicado: (2023)

Relationship of Dopamine of the Nucleus Accumbens with Intra-infralimbic Apomorphine Microinjection
por: Alimoradian, Abbas, et al.
Publicado: (2013)

Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson's Disease
por: Isaacson, Stuart, et al.
Publicado: (2016)

Investigation into the Action of Apomorphin as an Emetic in Its Physiological and Therapeutic Relations
por: Riegel, Franz, et al.
Publicado: (1872)

The Many Faces of Apomorphine: Lessons from the Past and Challenges for the Future
por: Auffret, Manon, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gn50doi2pjeqrs5oltbbjmfe91