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A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles

Professional athletes undertake a variety of training programs to enhance their physical performance, technical-tactical skills, while protecting their health and well-being. Regular exercise induces widespread changes in the whole body in an extremely complex network of signaling, and evidence indi...

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Autores principales: Rodas, Gil, Ferrer, Eva, Reche, Xavier, Sanjuan-Herráez, Juan Daniel, McCall, Alan, Quintás, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561103/
https://www.ncbi.nlm.nih.gov/pubmed/36246100
http://dx.doi.org/10.3389/fphys.2022.923608
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author Rodas, Gil
Ferrer, Eva
Reche, Xavier
Sanjuan-Herráez, Juan Daniel
McCall, Alan
Quintás, Guillermo
author_facet Rodas, Gil
Ferrer, Eva
Reche, Xavier
Sanjuan-Herráez, Juan Daniel
McCall, Alan
Quintás, Guillermo
author_sort Rodas, Gil
collection PubMed
description Professional athletes undertake a variety of training programs to enhance their physical performance, technical-tactical skills, while protecting their health and well-being. Regular exercise induces widespread changes in the whole body in an extremely complex network of signaling, and evidence indicates that phenotypical sex differences influence the physiological adaptations to player load of professional athletes. Despite that there remains an underrepresentation of women in clinical studies in sports, including football. The objectives of this study were twofold: to study the association between the external load (EPTS) and urinary metabolites as a surrogate of the adaptation to training, and to assess the effect of sex on the physiological adaptations to player load in professional football players. Targeted metabolic analysis of aminoacids, and tryptophan and phenylalanine metabolites detected progressive changes in the urinary metabolome associated with the external training load in men and women’s football teams. Overrepresentation analysis and multivariate analysis of metabolic data showed significant differences of the effect of training on the metabolic profiles in the men and women teams analyzed. Collectively, our results demonstrate that the development of metabolic models of adaptation in professional football players can benefit from the separate analysis of women and men teams, providing more accurate insights into how adaptation to the external load is related to changes in the metabolic phenotypes. Furthermore, results support the use of metabolomics to understand changes in specific metabolic pathways provoked by the training process.
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spelling pubmed-95611032022-10-15 A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles Rodas, Gil Ferrer, Eva Reche, Xavier Sanjuan-Herráez, Juan Daniel McCall, Alan Quintás, Guillermo Front Physiol Physiology Professional athletes undertake a variety of training programs to enhance their physical performance, technical-tactical skills, while protecting their health and well-being. Regular exercise induces widespread changes in the whole body in an extremely complex network of signaling, and evidence indicates that phenotypical sex differences influence the physiological adaptations to player load of professional athletes. Despite that there remains an underrepresentation of women in clinical studies in sports, including football. The objectives of this study were twofold: to study the association between the external load (EPTS) and urinary metabolites as a surrogate of the adaptation to training, and to assess the effect of sex on the physiological adaptations to player load in professional football players. Targeted metabolic analysis of aminoacids, and tryptophan and phenylalanine metabolites detected progressive changes in the urinary metabolome associated with the external training load in men and women’s football teams. Overrepresentation analysis and multivariate analysis of metabolic data showed significant differences of the effect of training on the metabolic profiles in the men and women teams analyzed. Collectively, our results demonstrate that the development of metabolic models of adaptation in professional football players can benefit from the separate analysis of women and men teams, providing more accurate insights into how adaptation to the external load is related to changes in the metabolic phenotypes. Furthermore, results support the use of metabolomics to understand changes in specific metabolic pathways provoked by the training process. Frontiers Media S.A. 2022-09-30 /pmc/articles/PMC9561103/ /pubmed/36246100 http://dx.doi.org/10.3389/fphys.2022.923608 Text en Copyright © 2022 Rodas, Ferrer, Reche, Sanjuan-Herráez, McCall and Quintás. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rodas, Gil
Ferrer, Eva
Reche, Xavier
Sanjuan-Herráez, Juan Daniel
McCall, Alan
Quintás, Guillermo
A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles
title A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles
title_full A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles
title_fullStr A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles
title_full_unstemmed A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles
title_short A targeted metabolic analysis of football players and its association to player load: Comparison between women and men profiles
title_sort targeted metabolic analysis of football players and its association to player load: comparison between women and men profiles
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561103/
https://www.ncbi.nlm.nih.gov/pubmed/36246100
http://dx.doi.org/10.3389/fphys.2022.923608
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