Identification of compelling inhibitors of human norovirus 3CL protease to combat gastroenteritis: A structure-based virtual screening and molecular dynamics study

Human noroviruses (NV) are the most prevalent cause of sporadic and pandemic acute gastroenteritis. NV infections cause substantial morbidity and death globally, especially amongst the aged, immunocompromised individuals, and children. There are presently no authorized NV vaccines, small-molecule th...

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Detalles Bibliográficos
Autores principales: He, Shan, Nahhas, Alaa F., Habib, Alaa Hamed, Alshehri, Mohammed Ali, Alshamrani, Saleh, Asiri, Saeed A., Alnamshan, Mashael M., Helmi, Nawal, Al-Dhuayan, Ibtesam, Almulhim, Jawaher, Alharbi, Ahmed M., Su, Dongxiao, Kumari, Ankita, Rahaman, Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561104/
https://www.ncbi.nlm.nih.gov/pubmed/36247661
http://dx.doi.org/10.3389/fchem.2022.1034911

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