Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis

Co-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the antitumor effects of chimeric antigen receptor (CAR) T cells. However, the effects of trans-recognition between CSRs and PD-L1 expressed by activated CAR T cells remain unclear. Here, we design a CSR specific for PD-L1...

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Detalles Bibliográficos
Autores principales: Qin, Le, Cui, Yuanbin, Yuan, Tingjie, Chen, Dongmei, Zhao, Ruocong, Li, Shanglin, Jiang, Zhiwu, Wu, Qiting, Long, Youguo, Wang, Suna, Tang, Zhaoyang, Pan, Huixia, Li, Xiaoping, Wei, Wei, Yang, Jie, Luo, Xuequn, Zhang, Zhenfeng, Tang, Qiannan, Liu, Pentao, Weinkove, Robert, Yao, Yao, Qin, Dajiang, Thiery, Jean Paul, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561169/
https://www.ncbi.nlm.nih.gov/pubmed/36229619
http://dx.doi.org/10.1038/s41467-022-33793-w

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