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APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus

Multifunctional protein APE1/APEX1/HAP1/Ref-1 (designated as APE1) plays important roles in nuclease-mediated DNA repair and redox regulation in transcription. However, it is unclear how APE1 regulates the DNA damage response (DDR) pathways. Here we show that siRNA-mediated APE1-knockdown or APE1 in...

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Detalles Bibliográficos
Autores principales:	Li, Jia, Zhao, Haichao, McMahon, Anne, Yan, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561277/ https://www.ncbi.nlm.nih.gov/pubmed/36200829 http://dx.doi.org/10.1093/nar/gkac853

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