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Chromatin transitions triggered by LH density as epigenetic regulators of the genome

Motivated by experiments connecting linker histone (LH) deficiency to lymphoma progression and retinal disorders, we study by mesoscale chromatin modeling how LH density (ρ) induces gradual, as well sudden, changes in chromatin architecture and how the process depends on DNA linker length, LH bindin...

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Detalles Bibliográficos
Autores principales:	Portillo-Ledesma, Stephanie, Wagley, Meghna, Schlick, Tamar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561278/ https://www.ncbi.nlm.nih.gov/pubmed/36130289 http://dx.doi.org/10.1093/nar/gkac757

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