A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are responsible for aerobic respiration, it is e...

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Detalles Bibliográficos
Autores principales: Mikhailova, Alina G, Mikhailova, Alina A, Ushakova, Kristina, Tretiakov, Evgeny O, Iliushchenko, Dmitrii, Shamansky, Victor, Lobanova, Valeria, Kozenkov, Ivan, Efimenko, Bogdan, Yurchenko, Andrey A, Kozenkova, Elena, Zdobnov, Evgeny M, Makeev, Vsevolod, Yurov, Valerian, Tanaka, Masashi, Gostimskaya, Irina, Fleischmann, Zoe, Annis, Sofia, Franco, Melissa, Wasko, Kevin, Denisov, Stepan, Kunz, Wolfram S, Knorre, Dmitry, Mazunin, Ilya, Nikolaev, Sergey, Fellay, Jacques, Reymond, Alexandre, Khrapko, Konstantin, Gunbin, Konstantin, Popadin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561281/
https://www.ncbi.nlm.nih.gov/pubmed/36130228
http://dx.doi.org/10.1093/nar/gkac779

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